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    Qdpr quinoid dihydropteridine reductase [ Mus musculus (house mouse) ]

    Gene ID: 110391, updated on 21-Apr-2024

    Summary

    Official Symbol
    Qdprprovided by MGI
    Official Full Name
    quinoid dihydropteridine reductaseprovided by MGI
    Primary source
    MGI:MGI:97836
    See related
    Ensembl:ENSMUSG00000015806 AllianceGenome:MGI:97836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dhpr; PKU2; D5Ertd371e; 2610008L04Rik
    Summary
    Predicted to enable 6,7-dihydropteridine reductase activity; identical protein binding activity; and nucleotide binding activity. Predicted to be involved in L-phenylalanine catabolic process and tetrahydrobiopterin biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver adult (RPKM 202.3), cerebellum adult (RPKM 120.9) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    5 B3; 5 24.9 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (45591374..45607571, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (45434032..45450229, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930431F12 gene Neighboring gene DNA segment, Chr 5, ERATO Doi 615, expressed Neighboring gene predicted gene, 46912 Neighboring gene STARR-seq mESC enhancer starr_12993 Neighboring gene STARR-seq mESC enhancer starr_12994 Neighboring gene STARR-seq mESC enhancer starr_12995 Neighboring gene STARR-seq mESC enhancer starr_12996 Neighboring gene STARR-positive B cell enhancer ABC_E669 Neighboring gene STARR-positive B cell enhancer ABC_E6329 Neighboring gene STARR-seq mESC enhancer starr_12997 Neighboring gene clarin 2 Neighboring gene leucine aminopeptidase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 6,7-dihydropteridine reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 6,7-dihydropteridine reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADH binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NADH binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NADPH binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NADPH binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tetrahydrobiopterin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tetrahydrobiopterin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    dihydropteridine reductase
    Names
    HDHPR
    NP_077198.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024236.2NP_077198.1  dihydropteridine reductase

      See identical proteins and their annotated locations for NP_077198.1

      Status: VALIDATED

      Source sequence(s)
      AC092711, AK166694
      Consensus CDS
      CCDS19272.1
      UniProtKB/Swiss-Prot
      Q3TT09, Q8BVI4, Q9D0K4
      UniProtKB/TrEMBL
      A0A0G2JGJ1
      Related
      ENSMUSP00000015950.6, ENSMUST00000015950.12
      Conserved Domains (1) summary
      cd05334
      Location:7229
      DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      45591374..45607571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)