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    Ttc13 tetratricopeptide repeat domain 13 [ Mus musculus (house mouse) ]

    Gene ID: 234875, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ttc13provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 13provided by MGI
    Primary source
    MGI:MGI:2384573
    See related
    Ensembl:ENSMUSG00000037300 AllianceGenome:MGI:2384573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Orthologous to human TTC13 (tetratricopeptide repeat domain 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.6), thymus adult (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E2; 8 72.81 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125398066..125448748, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124671327..124722011, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23008 Neighboring gene calpain 9 Neighboring gene RIKEN cDNA 2310022B05 gene Neighboring gene VISTA enhancer mm1665 Neighboring gene predicted gene, 46058 Neighboring gene predicted gene, 30273 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:127246145-127246328 Neighboring gene ARV1 homolog, fatty acid homeostasis modulator Neighboring gene family with sequence similarity 89, member A Neighboring gene general transcription factor IIB pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28881, MGC105232

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357355.2 → NP_001344284.1  tetratricopeptide repeat protein 13 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC135015, AC151736
      Consensus CDS
      CCDS90481.1
      UniProtKB/TrEMBL
      E9Q723, Q3UMK4
      Related
      ENSMUSP00000113383.3, ENSMUST00000118134.3
      Conserved Domains (2) summary
      COG0457
      Location:130 → 314
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:181 → 209
      TPR; TPR repeat [structural motif]

    2. NM_001357356.2 → NP_001344285.1  tetratricopeptide repeat protein 13 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC135015, AC151736
      Consensus CDS
      CCDS90480.1
      UniProtKB/TrEMBL
      A0A338P6N2, Q3UMK4
      Related
      ENSMUSP00000156040.2, ENSMUST00000231984.2
      Conserved Domains (2) summary
      COG0457
      Location:71 → 238
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:173 → 201
      TPR; TPR repeat [structural motif]

    3. NM_001357357.2 → NP_001344286.1  tetratricopeptide repeat protein 13 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC135015, AC151736
      Consensus CDS
      CCDS90482.1
      UniProtKB/TrEMBL
      D3YVV0, Q3UMK4
      Related
      ENSMUSP00000114043.3, ENSMUST00000117624.9
      Conserved Domains (2) summary
      COG0457
      Location:99 → 260
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:164 → 189
      TPR; TPR repeat [structural motif]

    4. NM_001373939.1 → NP_001360868.1  tetratricopeptide repeat protein 13 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC135015, AC151736
      UniProtKB/TrEMBL
      Q3UMK4
      Conserved Domains (2) summary
      TIGR02917
      Location:104 → 403
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:234 → 262
      TPR; TPR repeat [structural motif]

    5. NM_001373940.1 → NP_001360869.1  tetratricopeptide repeat protein 13 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC135015, AC151736
      UniProtKB/TrEMBL
      Q3UMK4
      Conserved Domains (2) summary
      COG0457
      Location:130 → 314
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:181 → 209
      TPR; TPR repeat [structural motif]

    6. NM_001373941.1 → NP_001360870.1  tetratricopeptide repeat protein 13 isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      AC135015, AC151736
      UniProtKB/TrEMBL
      Q3UMK4
      Related
      ENSMUSP00000038484.9, ENSMUST00000041614.15
      Conserved Domains (2) summary
      COG0457
      Location:71 → 238
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:173 → 201
      TPR; TPR repeat [structural motif]

    7. NM_001373943.1 → NP_001360872.1  tetratricopeptide repeat protein 13 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC135015, AC151736
      Consensus CDS
      CCDS90483.1
      UniProtKB/TrEMBL
      A0A1L1SSC7, Q3UMK4
      Related
      ENSMUSP00000149848.2, ENSMUST00000214828.2
      Conserved Domains (2) summary
      TIGR02917
      Location:104 → 403
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:234 → 262
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      125398066..125448748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153978.1 → XP_036009871.1  tetratricopeptide repeat protein 13 isoform X2

      UniProtKB/TrEMBL
      Q3UMK4
      Conserved Domains (2) summary
      TIGR02917
      Location:104 → 372
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:203 → 231
      TPR; TPR repeat [structural motif]

    2. XM_006530966.5 → XP_006531029.1  tetratricopeptide repeat protein 13 isoform X1

      UniProtKB/TrEMBL
      Q3UMK4
      Conserved Domains (2) summary
      TIGR02917
      Location:104 → 372
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:203 → 231
      TPR; TPR repeat [structural motif]

    3. XM_017312765.1 → XP_017168254.1  tetratricopeptide repeat protein 13 isoform X4

      UniProtKB/TrEMBL
      Q68FG8
      Conserved Domains (1) summary
      sd00006
      Location:26 → 56
      TPR; TPR repeat [structural motif]

    4. XM_036153979.1 → XP_036009872.1  tetratricopeptide repeat protein 13 isoform X3

      Conserved Domains (2) summary
      TIGR02917
      Location:104 → 403
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:234 → 262
      TPR; TPR repeat [structural motif]

    RNA

    1. XR_001778436.2 RNA Sequence

    2. XR_878807.4 RNA Sequence

    3. XR_004934821.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145607.3: Suppressed sequence

      Description
      NM_145607.3: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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