Gbp6 guanylate binding protein 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gbp6provided by MGI
Official Full Name: guanylate binding protein 6provided by MGI
Primary source: MGI:MGI:2140937
See related: Ensembl:ENSMUSG00000104713 AllianceGenome:MGI:2140937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GBP-6; Mpa2l
Summary: Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within several processes, including cellular response to interferon-beta; cellular response to lipopolysaccharide; and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Is expressed in several structures, including alimentary system; dorsal root ganglion; nasal cavity epithelium; vertebral axis musculature; and vibrissa. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thymus adult (RPKM 7.3), liver E18 (RPKM 5.1) and 24 other tissues See more
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Genomic context

Location:: 5 E5; 5 50.68 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (105418568..105443733, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (105270702..105295871, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings show that at least 4 IFN-gamma-inducible Gbps--Gbp1, Gbp6, Gbp7, and Gbp10--conferred cell-autonomous immunity to listerial or mycobacterial infection within macrophages and gene-deficient animals
Title: A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adhesion of symbiont to host	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to protozoan	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to protozoan	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in symbiont-containing vacuole membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanylate-binding protein 6

Names: GTP-binding protein 6; guanine nucleotide-binding protein 6; macrophage activation 2 like; macrophage activation 2 like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194336.2 → NP_919317.2 guanylate-binding protein 6

See identical proteins and their annotated locations for NP_919317.2

Status: VALIDATED

Source sequence(s)

AC123697, AK152226, BB657433, BQ562803, BX525828, BY159737

Consensus CDS

CCDS19492.1

UniProtKB/Swiss-Prot

A0A0G2JDV3, Q6PEN2, Q6ZQL8

UniProtKB/TrEMBL

A0A8Q0QEH4, L7N1X8

Related

ENSMUSP00000142518.2, ENSMUST00000196520.2

Conserved Domains (2) summary

pfam02263
Location:16 → 279

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:281 → 575

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

105418568..105443733 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534688.4 → XP_006534751.1 guanylate-binding protein 6 isoform X4

UniProtKB/Swiss-Prot

A0A0G2JDV3, Q6PEN2, Q6ZQL8

UniProtKB/TrEMBL

L7N1X8

Conserved Domains (2) summary

pfam02841
Location:231 → 525

GBP_C; Guanylate-binding protein, C-terminal domain

cl38936
Location:10 → 229

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006534687.4 → XP_006534750.1 guanylate-binding protein 6 isoform X2

See identical proteins and their annotated locations for XP_006534750.1

UniProtKB/Swiss-Prot

A0A0G2JDV3, Q6PEN2, Q6ZQL8

UniProtKB/TrEMBL

A0A8Q0QEH4, L7N1X8

Conserved Domains (2) summary

pfam02263
Location:16 → 279

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:281 → 575

GBP_C; Guanylate-binding protein, C-terminal domain
XM_006534690.5 → XP_006534753.2 guanylate-binding protein 6 isoform X3

UniProtKB/TrEMBL

Q05DL4

Conserved Domains (2) summary

pfam02841
Location:258 → 552

GBP_C; Guanylate-binding protein, C-terminal domain

cl38936
Location:81 → 256

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_006534689.5 → XP_006534752.1 guanylate-binding protein 6 isoform X5

See identical proteins and their annotated locations for XP_006534752.1

UniProtKB/TrEMBL

Q05DL4

Conserved Domains (2) summary

pfam02841
Location:204 → 498

GBP_C; Guanylate-binding protein, C-terminal domain

cl38936
Location:1 → 202

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_011249385.4 → XP_011247687.1 guanylate-binding protein 6 isoform X1

UniProtKB/Swiss-Prot

A0A0G2JDV3, Q6PEN2, Q6ZQL8

UniProtKB/TrEMBL

L7N1X8

Conserved Domains (2) summary

pfam02263
Location:105 → 368

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:370 → 664

GBP_C; Guanylate-binding protein, C-terminal domain
XM_006534691.3 → XP_006534754.1 guanylate-binding protein 6 isoform X5

See identical proteins and their annotated locations for XP_006534754.1

UniProtKB/TrEMBL

Q05DL4

Conserved Domains (2) summary

pfam02841
Location:204 → 498

GBP_C; Guanylate-binding protein, C-terminal domain

cl38936
Location:1 → 202

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases