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    Tex10 testis expressed gene 10 [ Mus musculus (house mouse) ]

    Gene ID: 269536, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tex10provided by MGI
    Official Full Name
    testis expressed gene 10provided by MGI
    Primary source
    MGI:MGI:1344413
    See related
    Ensembl:ENSMUSG00000028345 AllianceGenome:MGI:1344413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610206N19Rik; 2810462N03Rik
    Summary
    Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of MLL1 complex. Predicted to be active in nucleus. Orthologous to human TEX10 (testis expressed 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 12.4), placenta adult (RPKM 9.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 B1; 4 26.13 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (48430805..48473492, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (48430858..48473464, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10154 Neighboring gene endoplasmic reticulum protein 44 Neighboring gene STARR-positive B cell enhancer ABC_E6176 Neighboring gene microRNA 1958 Neighboring gene STARR-positive B cell enhancer ABC_E6177 Neighboring gene STARR-seq mESC enhancer starr_10155 Neighboring gene STARR-positive B cell enhancer ABC_E1644 Neighboring gene STARR-seq mESC enhancer starr_10157 Neighboring gene inversin Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6178 Neighboring gene STARR-seq mESC enhancer starr_10161 Neighboring gene STARR-seq mESC enhancer starr_10162 Neighboring gene STARR-seq mESC enhancer starr_10163 Neighboring gene STARR-seq mESC enhancer starr_10164 Neighboring gene Myb/SANT-like DNA-binding domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_10167 Neighboring gene transmembrane protein with EGF-like and two follistatin-like domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. Ding J, et al. Cell Stem Cell, 2015 Jun 4. PMID 25936917, Free PMC Article
    2. Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse. Morgan D, et al. Nat Genet, 1998 Oct. PMID 9771707
    3. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Fanis P, et al. Mol Cell Proteomics, 2012 Nov. PMID 22872859, Free PMC Article
    4. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article
    5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tex10 interacts with STAT3 to regulate hepatocellular carcinoma growth and metastasis.
      Title: Tex10 interacts with STAT3 to regulate hepatocellular carcinoma growth and metastasis.
    2. Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC]
      Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
    3. Tex10 is a core component of the pluripotency network.
      Title: Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11792

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of MLL1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testis-expressed protein 10
    Names
    clone 18330
    testis-expressed sequence 10 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355740.1 → NP_001342669.1  testis-expressed protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK141288, CA539714, CJ082426, DV645036
      Consensus CDS
      CCDS38760.1
      UniProtKB/Swiss-Prot
      Q3URQ0
      Related
      ENSMUSP00000030030.9, ENSMUST00000030030.15
      Conserved Domains (1) summary
      pfam12333
      Location:132 → 235
      Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

    2. NM_001355741.1 → NP_001342670.1  testis-expressed protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK141288, CA539714, CJ082426, DV645036

    3. NM_172304.4 → NP_758508.2  testis-expressed protein 10 isoform 1

      See identical proteins and their annotated locations for NP_758508.2

      Status: VALIDATED

      Source sequence(s)
      AK132870, AK141288, CJ082426, DV645036
      Consensus CDS
      CCDS38760.1
      UniProtKB/Swiss-Prot
      Q3URQ0
      Related
      ENSMUSP00000132498.2, ENSMUST00000164866.2
      Conserved Domains (1) summary
      pfam12333
      Location:132 → 235
      Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      48430805..48473492 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537956.4 → XP_006538019.1  testis-expressed protein 10 isoform X1

      See identical proteins and their annotated locations for XP_006538019.1

      UniProtKB/Swiss-Prot
      Q3URQ0
      Conserved Domains (1) summary
      pfam12333
      Location:132 → 235
      Ipi1_N; Rix1 complex component involved in 60S ribosome maturation

    2. XM_036164139.1 → XP_036020032.1  testis-expressed protein 10 isoform X2

      Conserved Domains (1) summary
      pfam12333
      Location:132 → 235
      Ipi1_N; Rix1 complex component involved in 60S ribosome maturation
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3URQ0.1 GenPept UniProtKB/Swiss-Prot:Q3URQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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