Acot2 acyl-CoA thioesterase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acot2provided by MGI
Official Full Name: acyl-CoA thioesterase 2provided by MGI
Primary source: MGI:MGI:2159605
See related: Ensembl:ENSMUSG00000021226 AllianceGenome:MGI:2159605
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mte1; MTE-I
Summary: Predicted to enable palmitoyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process; fatty acid metabolic process; and response to hypoxia. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACOT1 (acyl-CoA thioesterase 1) and ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 20.3), heart adult (RPKM 16.9) and 27 other tissues See more
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Genomic context

Location:: 12 D1; 12 38.99 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (84034635..84040651)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (83987861..83993877)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The CoA-insensitive Acot2 could provide a constitutive siphon for long-chain fatty acyl-CoAs.
Title: Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles.
MiR-27b-3p induces acyl-CoA thioesterase 2 (ACOT2) expression in 3T3-L1 cells.
Title: Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via Induction of Acyl-CoA Thioesterase 2 Expression.
Data suggest that ACOT2 contributes to oxidation of fatty acids in liver mitochondria when demand for ATP is low and fatty acids are the prevailing substrate for energy metabolism; ACOT2 also contributes to prevention of fatty steatosis in liver.
Title: Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Acot2 (e-PCR), detects polymorphism
- UniSTS:546625

NoName (e-PCR)
- UniSTS:236904

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables fatty acyl-CoA hydrolase activity	TAS Traceable Author Statement more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables thiolester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acyl-CoA metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty-acyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 2, mitochondrial

Names: acyl coenzyme A thioester hydrolase; mitochondrial acyl-CoA thioesterase 1; very-long-chain acyl-CoA thioesterase

NP_598949.3

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134188.3 → NP_598949.3 acyl-coenzyme A thioesterase 2, mitochondrial precursor

See identical proteins and their annotated locations for NP_598949.3

Status: VALIDATED

Source sequence(s)

AC133183, AK141651, BC064469

Consensus CDS

CCDS26034.1

UniProtKB/Swiss-Prot

Q3T9C9, Q9QYR9

UniProtKB/TrEMBL

Q6P2K2

Related

ENSMUSP00000021649.8, ENSMUST00000021649.8

Conserved Domains (3) summary

pfam04775
Location:58 → 178

Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

pfam08840
Location:244 → 451

BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

cl21494
Location:186 → 298

Abhydrolase; alpha/beta hydrolases