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    Smim22 small integral membrane protein 22 [ Mus musculus (house mouse) ]

    Gene ID: 432995, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Smim22provided by MGI
    Official Full Name
    small integral membrane protein 22provided by MGI
    Primary source
    MGI:MGI:3643379
    See related
    Ensembl:ENSMUSG00000096215 AllianceGenome:MGI:3643379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5480; EG432995
    Summary
    Predicted to be involved in several processes, including lipid droplet formation; positive regulation of cell migration; and regulation of actin cytoskeleton organization. Is expressed in embryo; embryo endoderm; and node. Orthologous to human SMIM22 (small integral membrane protein 22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 69.0), duodenum adult (RPKM 56.5) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 A1; 16 2.49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4825152..4826173)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5007288..5008309)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene septin 12 Neighboring gene STARR-positive B cell enhancer ABC_E7426 Neighboring gene rogdi homolog Neighboring gene glyoxylate reductase 1 homolog (Arabidopsis) Neighboring gene STARR-positive B cell enhancer ABC_E1180

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. The transcriptional landscape of the mammalian genome. Carninci P, et al. Science, 2005 Sep 2. PMID 16141072
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    small integral membrane protein 22

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253796.1 → NP_001240725.1  small integral membrane protein 22 isoform 1

      See identical proteins and their annotated locations for NP_001240725.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC163723, BB610432, CJ320043
      Consensus CDS
      CCDS57017.1
      UniProtKB/TrEMBL
      J3QP37
      Related
      ENSMUSP00000137083.2, ENSMUST00000178155.9
      Conserved Domains (1) summary
      pfam15831
      Location:10 → 58
      DUF4713; Domain of unknown function (DUF4713)

    2. NM_001253797.1 → NP_001240726.1  small integral membrane protein 22 isoform 2

      See identical proteins and their annotated locations for NP_001240726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform 2 is shorter than isoform 1. Both variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AC163723, CJ237462
      Consensus CDS
      CCDS70681.1
      UniProtKB/TrEMBL
      V9GXA9
      Related
      ENSMUSP00000139067.2, ENSMUST00000185147.8
      Conserved Domains (1) summary
      pfam15831
      Location:10 → 58
      DUF4713; Domain of unknown function (DUF4713)

    3. NM_001253802.1 → NP_001240731.1  small integral membrane protein 22 isoform 1

      See identical proteins and their annotated locations for NP_001240731.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC163723, CJ043101
      Consensus CDS
      CCDS57017.1
      UniProtKB/TrEMBL
      J3QP37
      Related
      ENSMUSP00000139370.2, ENSMUST00000184439.8
      Conserved Domains (1) summary
      pfam15831
      Location:10 → 58
      DUF4713; Domain of unknown function (DUF4713)

    4. NM_001253803.1 → NP_001240732.1  small integral membrane protein 22 isoform 2

      See identical proteins and their annotated locations for NP_001240732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Both variants 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AC163723, AW985536
      Consensus CDS
      CCDS70681.1
      UniProtKB/TrEMBL
      V9GXA9
      Conserved Domains (1) summary
      pfam15831
      Location:10 → 58
      DUF4713; Domain of unknown function (DUF4713)

    RNA

    1. NR_045595.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC163723
      Related
      ENSMUST00000184256.7

    2. NR_045596.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AC163723
      Related
      ENSMUST00000183381.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4825152..4826173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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