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    Bicra BRD4 interacting chromatin remodeling complex associated protein [ Mus musculus (house mouse) ]

    Gene ID: 243842, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Bicraprovided by MGI
    Official Full Name
    BRD4 interacting chromatin remodeling complex associated proteinprovided by MGI
    Primary source
    MGI:MGI:2154263
    See related
    Ensembl:ENSMUSG00000070808 AllianceGenome:MGI:2154263
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gltscr1
    Summary
    Predicted to enable transcription regulator activator activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome. Orthologous to human BICRA (BRD4 interacting chromatin remodeling complex associated protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 18.0), spleen adult (RPKM 18.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A2; 7 8.67 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15704596..15785047, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (15970671..16048146, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2814 Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene NOP53 ribosome biogenesis factor Neighboring gene predicted gene, 24576 Neighboring gene EH-domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11342 Neighboring gene STARR-seq mESC enhancer starr_18118 Neighboring gene STARR-seq mESC enhancer starr_18119 Neighboring gene predicted gene, 38948 Neighboring gene RIKEN cDNA 2010004M13 gene Neighboring gene STARR-positive B cell enhancer ABC_E6514 Neighboring gene STARR-positive B cell enhancer ABC_E1078 Neighboring gene STARR-positive B cell enhancer ABC_E4897 Neighboring gene STARR-positive B cell enhancer ABC_E2815 Neighboring gene zinc finger protein 541 Neighboring gene STARR-seq mESC enhancer starr_18124 Neighboring gene STARR-positive B cell enhancer ABC_E541 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription. Han F, et al. Angiogenesis, 2023 May. PMID 36745292, Free PMC Article
    2. The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice. Hong HK, et al. Proc Natl Acad Sci U S A, 2004 Feb 10. PMID 14755058, Free PMC Article
    3. Mapping of the mouse hyh gene to a YAC/BAC contig on proximal Chromosome 7. Chae TH, et al. Mamm Genome, 2002 May. PMID 12016511
    4. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Gatchalian J, et al. Nat Commun, 2018 Dec 3. PMID 30510198, Free PMC Article
    5. An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency. Ho L, et al. Proc Natl Acad Sci U S A, 2009 Mar 31. PMID 19279220, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription.
      Title: Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription regulator activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GBAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BRD4-interacting chromatin-remodeling complex-associated protein
    Names
    glioma tumor suppressor candidate region gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081418.1 → NP_001074887.1  BRD4-interacting chromatin-remodeling complex-associated protein

      See identical proteins and their annotated locations for NP_001074887.1

      Status: PROVISIONAL

      Source sequence(s)
      AC148990
      Consensus CDS
      CCDS39780.1
      UniProtKB/Swiss-Prot
      F8VPZ9
      Related
      ENSMUSP00000092416.4, ENSMUST00000094821.4
      Conserved Domains (3) summary
      PHA03247
      Location:321 → 935
      PHA03247; large tegument protein UL36; Provisional
      PRK14086
      Location:1383 → 1561
      dnaA; chromosomal replication initiator protein DnaA
      pfam15249
      Location:1101 → 1202
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      15704596..15785047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242555.2 → XP_030098415.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X4

      Conserved Domains (3) summary
      PHA03247
      Location:299 → 858
      PHA03247; large tegument protein UL36; Provisional
      PRK14086
      Location:1302 → 1480
      dnaA; chromosomal replication initiator protein DnaA
      pfam15249
      Location:1020 → 1121
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    2. XM_006539918.5 → XP_006539981.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:299 → 913
      PHA03247; large tegument protein UL36; Provisional
      PRK14086
      Location:1361 → 1539
      dnaA; chromosomal replication initiator protein DnaA
      pfam15249
      Location:1079 → 1180
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    3. XM_011250559.4 → XP_011248861.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X3

      Conserved Domains (3) summary
      PHA03247
      Location:321 → 880
      PHA03247; large tegument protein UL36; Provisional
      PRK14086
      Location:1324 → 1502
      dnaA; chromosomal replication initiator protein DnaA
      pfam15249
      Location:1042 → 1143
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    4. XM_006539917.5 → XP_006539980.1  BRD4-interacting chromatin-remodeling complex-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006539980.1

      UniProtKB/Swiss-Prot
      F8VPZ9
      Related
      ENSMUSP00000148012.2, ENSMUST00000210781.2
      Conserved Domains (3) summary
      PHA03247
      Location:321 → 935
      PHA03247; large tegument protein UL36; Provisional
      PRK14086
      Location:1383 → 1561
      dnaA; chromosomal replication initiator protein DnaA
      pfam15249
      Location:1101 → 1202
      GLTSCR1; Conserved region of unknown function on GLTSCR protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F8VPZ9.1 GenPept UniProtKB/Swiss-Prot:F8VPZ9

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