Exph5 exophilin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Exph5provided by MGI
Official Full Name: exophilin 5provided by MGI
Primary source: MGI:MGI:2443248
See related: Ensembl:ENSMUSG00000034584 AllianceGenome:MGI:2443248
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Slac2b; slac2-b; Kiaa0624; E030050P12; B130009M24Rik; AC079869.22gm5
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in keratinocyte development; multivesicular body sorting pathway; and positive regulation of secretion by cell. Predicted to be active in endosome. Orthologous to human EXPH5 (exophilin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 6.3), large intestine adult (RPKM 1.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 29.12 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (53212814..53292466)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (53301514..53381166)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses.
Title: Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte development	ISO Inferred from Sequence Orthology more info
involved_in multivesicular body sorting pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exophilin-5

Names: slp homolog lacking C2 domains b; synaptotagmin-like homologue lacking C2 domains b; synaptotagmin-like protein homolog lacking C2 domains b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176846.3 → NP_789816.2 exophilin-5

See identical proteins and their annotated locations for NP_789816.2

Status: VALIDATED

Source sequence(s)

AC079869, AC160139, BC120905

Consensus CDS

CCDS23181.1

UniProtKB/Swiss-Prot

Q0VAV2, Q3UNV5, Q6A034, Q812E3

Related

ENSMUSP00000062632.2, ENSMUST00000051014.2

Conserved Domains (2) summary

pfam15449
Location:1588 → 1766

Retinal; Retinal protein

cl22851
Location:11 → 46

PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

53212814..53292466

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510425.5 → XP_006510488.1 exophilin-5 isoform X1

See identical proteins and their annotated locations for XP_006510488.1

UniProtKB/Swiss-Prot

Q0VAV2, Q3UNV5, Q6A034, Q812E3

Conserved Domains (2) summary

pfam15449
Location:1588 → 1766

Retinal; Retinal protein

cl22851
Location:11 → 46

PHD_SF; PHD finger superfamily
XM_017313428.3 → XP_017168917.1 exophilin-5 isoform X2

Conserved Domains (1) summary

pfam15449
Location:1512 → 1690

Retinal; Retinal protein
XM_017313429.1 → XP_017168918.1 exophilin-5 isoform X3

Conserved Domains (1) summary

pfam15449
Location:1403 → 1581

Retinal; Retinal protein
XM_017313430.3 → XP_017168919.1 exophilin-5 isoform X4

Conserved Domains (1) summary

pfam15449
Location:1364 → 1542

Retinal; Retinal protein