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    Tpgs2 tubulin polyglutamylase complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 66648, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tpgs2provided by MGI
    Official Full Name
    tubulin polyglutamylase complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1913898
    See related
    Ensembl:ENSMUSG00000024269 AllianceGenome:MGI:1913898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pgs2; 5730437P09Rik; 5730494M16Rik
    Summary
    Predicted to be involved in protein polyglutamylation. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TPGS2 (tubulin polyglutamylase complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 26.1), whole brain E14.5 (RPKM 7.5) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tpgs2 in Genome Data Viewer
    Location:
    18 A2; 18 13.69 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (25260280..25301990, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (25127223..25168933, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr18:24835661-24835962 Neighboring gene molybdenum cofactor sulfurase Neighboring gene formin homology 2 domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_44073 Neighboring gene 39S ribosomal protein L42, mitochondrial pseudogene Neighboring gene STARR-seq mESC enhancer starr_44075 Neighboring gene expressed sequence AW554918 Neighboring gene STARR-seq mESC enhancer starr_44077 Neighboring gene STARR-seq mESC enhancer starr_44078 Neighboring gene STARR-seq mESC enhancer starr_44080 Neighboring gene predicted gene, 32825 Neighboring gene CUGBP, Elav-like family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E3225 Neighboring gene predicted gene 3227

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843
    2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91164

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein polyglutamylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin polyglutamylase complex subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004361.2 → NP_001004361.2  tubulin polyglutamylase complex subunit 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC124441, AI666318, AK017728, BC060253, BQ770487
      Consensus CDS
      CCDS29105.2
      UniProtKB/Swiss-Prot
      Q66JT5, Q6PAK1
      UniProtKB/TrEMBL
      E9QLP0
      Related
      ENSMUSP00000111484.3, ENSMUST00000115817.3
      Conserved Domains (1) summary
      smart00860
      Location:43 → 192
      SMI1_KNR4; SMI1 / KNR4 family

    2. NM_001142697.1 → NP_001136169.1  tubulin polyglutamylase complex subunit 2 isoform b

      See identical proteins and their annotated locations for NP_001136169.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC124441, AI666318, DV655125
      UniProtKB/Swiss-Prot
      Q66JT5, Q6PAK1
      Conserved Domains (1) summary
      smart00860
      Location:2 → 145
      SMI1_KNR4; SMI1 / KNR4 family

    3. NM_001142698.1 → NP_001136170.1  tubulin polyglutamylase complex subunit 2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC124441, AK141632, BC060253, BQ770487
      Consensus CDS
      CCDS50240.1
      UniProtKB/TrEMBL
      E9PUD7
      Related
      ENSMUSP00000122538.2, ENSMUST00000148255.8
      Conserved Domains (1) summary
      smart00860
      Location:43 → 192
      SMI1_KNR4; SMI1 / KNR4 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      25260280..25301990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526156.5 → XP_006526219.1  tubulin polyglutamylase complex subunit 2 isoform X1

    RNA

    1. XR_003952537.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66JT5.2 GenPept UniProtKB/Swiss-Prot:Q66JT5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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