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    Gtdc1 glycosyltransferase-like domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 227835, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gtdc1provided by MGI
    Official Full Name
    glycosyltransferase-like domain containing 1provided by MGI
    Primary source
    MGI:MGI:2444269
    See related
    Ensembl:ENSMUSG00000036890 AllianceGenome:MGI:2444269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E330008O22Rik
    Summary
    Predicted to enable glycosyltransferase activity. Is expressed in brain; spinal cord; and telencephalon marginal layer. Orthologous to human GTDC1 (glycosyltransferase like domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 8.8), CNS E18 (RPKM 7.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 27.27 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (44454420..44817761, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (44564412..44927717, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39805 Neighboring gene STARR-seq mESC enhancer starr_04394 Neighboring gene STARR-seq mESC enhancer starr_04398 Neighboring gene predicted gene, 39806 Neighboring gene predicted gene, 52509 Neighboring gene predicted gene, 39807 Neighboring gene STARR-seq mESC enhancer starr_04399 Neighboring gene centromere protein C1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:44816144-44816341 Neighboring gene STARR-seq mESC enhancer starr_04400 Neighboring gene zinc finger E-box binding homeobox 2 Neighboring gene microRNA 5129 Neighboring gene zinc finger E-box binding homeobox 2, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables tRNA-queuosine(34) beta-mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycosyltransferase-like domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362986.1 → NP_001349915.1  glycosyltransferase-like domain-containing protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AL844891, AL929120, AL935057, BX293544
      Consensus CDS
      CCDS71050.1
      UniProtKB/Swiss-Prot
      A2AQR9, A2AQS2, A2AVU2, Q3TQ41, Q80US3, Q8BW56, Q8C1B8
      UniProtKB/TrEMBL
      G8JL42
      Conserved Domains (2) summary
      cd01635
      Location:275 → 386
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
      pfam12038
      Location:2 → 164
      DUF3524; Domain of unknown function (DUF3524)

    2. NM_001362987.1 → NP_001349916.1  glycosyltransferase-like domain-containing protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AL844891, AL929120, AL935057, BX293544
      Consensus CDS
      CCDS71050.1
      UniProtKB/Swiss-Prot
      A2AQR9, A2AQS2, A2AVU2, Q3TQ41, Q80US3, Q8BW56, Q8C1B8
      UniProtKB/TrEMBL
      G8JL42
      Related
      ENSMUSP00000038119.7, ENSMUST00000049051.13
      Conserved Domains (2) summary
      cd01635
      Location:275 → 386
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
      pfam12038
      Location:2 → 164
      DUF3524; Domain of unknown function (DUF3524)

    3. NM_172662.3 → NP_766250.2  glycosyltransferase-like domain-containing protein 1

      See identical proteins and their annotated locations for NP_766250.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents a protein-coding transcript, as do variants 2 and 3. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK054272, BC052069
      Consensus CDS
      CCDS71050.1
      UniProtKB/Swiss-Prot
      A2AQR9, A2AQS2, A2AVU2, Q3TQ41, Q80US3, Q8BW56, Q8C1B8
      UniProtKB/TrEMBL
      G8JL42
      Related
      ENSMUSP00000108429.2, ENSMUST00000112810.8
      Conserved Domains (2) summary
      cd01635
      Location:275 → 386
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
      pfam12038
      Location:2 → 164
      DUF3524; Domain of unknown function (DUF3524)

    RNA

    1. NR_156429.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK038057, AL929120, AL935057

    2. NR_156430.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK163943, AL935057
      Related
      ENSMUST00000100127.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      44454420..44817761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239091.3 → XP_011237393.1  glycosyltransferase-like domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011237393.1

      UniProtKB/Swiss-Prot
      A2AQR9, A2AQS2, A2AVU2, Q3TQ41, Q80US3, Q8BW56, Q8C1B8
      UniProtKB/TrEMBL
      G8JL42
      Conserved Domains (2) summary
      cd01635
      Location:275 → 386
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
      pfam12038
      Location:2 → 164
      DUF3524; Domain of unknown function (DUF3524)

    2. XM_030250118.2 → XP_030105978.1  glycosyltransferase-like domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam12038
      Location:2 → 164
      DUF3524; Domain of unknown function (DUF3524)

    RNA

    1. XR_003952199.2 RNA Sequence

    2. XR_003952196.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BW56.2 GenPept UniProtKB/Swiss-Prot:Q8BW56

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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