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    Zfp703 zinc finger protein 703 [ Mus musculus (house mouse) ]

    Gene ID: 353310, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp703provided by MGI
    Official Full Name
    zinc finger protein 703provided by MGI
    Primary source
    MGI:MGI:2662729
    See related
    Ensembl:ENSMUSG00000085795 AllianceGenome:MGI:2662729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    End2; Zpo1; Csmn1; Zeppo1; Znf703; 1110032O19Rik
    Summary
    Enables DNA-binding transcription factor binding activity. Involved in several processes, including adherens junction assembly; positive regulation of mammary gland epithelial cell proliferation; and regulation of signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; extraembryonic component; eye; tooth; and urinary system. Orthologous to human ZNF703 (zinc finger protein 703). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 77.2), duodenum adult (RPKM 36.8) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp703 in Genome Data Viewer
    Location:
    8 A2; 8 15.91 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27467364..27471490)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (26977336..26981462)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1598 Neighboring gene predicted gene, 53408 Neighboring gene STARR-positive B cell enhancer ABC_E4993 Neighboring gene predicted gene, 39150 Neighboring gene predicted gene 45572 Neighboring gene STARR-seq mESC enhancer starr_21011 Neighboring gene predicted gene 45370 Neighboring gene predicted gene, 32389

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of human NLZ1/ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression. Pereira-Castro I, et al. J Cell Biochem, 2013 Jan. PMID 22886885
    2. Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex. Kumar A, et al. Mol Cell Biol, 2016 Jun 15. PMID 27090637, Free PMC Article
    3. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Slorach EM, et al. Genes Dev, 2011 Mar 1. PMID 21317240, Free PMC Article
    4. ES cell neural differentiation reveals a substantial number of novel ESTs. Bain G, et al. Funct Integr Genomics, 2000 Sep. PMID 11793228
    5. Hoxa2 selectively enhances Meis binding to change a branchial arch ground state. Amin S, et al. Dev Cell, 2015 Feb 9. PMID 25640223, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results provide evidence that Zfp703 is a novel feedback suppressor of Wnt/beta-catenin signaling that functions by inhibiting the association of beta-catenin with Tcf1 on Wnt response elements in target gene enhancers.
      Title: Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex.
    2. The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein.
      Title: Characterization of human NLZ1/ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression.
    3. Zeppo1 is a key regulator of breast cancer progression
      Title: Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mammary gland epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of homotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mammary gland epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 703
    Names
    ES neuronal differentiation 2
    zinc finger elbow-related proline domain protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101502.1 → NP_001094972.1  zinc finger protein 703 isoform 1

      See identical proteins and their annotated locations for NP_001094972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA008919, AC115820, BB609653, BE685996, BE981624, BF323167, BF464968, BQ964921, CD352751, CF582327
      Consensus CDS
      CCDS52532.1
      UniProtKB/Swiss-Prot
      P0CL69
      UniProtKB/TrEMBL
      F6M3K1
      Related
      ENSMUSP00000128757.2, ENSMUST00000154256.3
      Conserved Domains (2) summary
      sd00017
      Location:462 → 488
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12402
      Location:315 → 369
      nlz1; NocA-like zinc-finger protein 1

    2. NM_001110508.1 → NP_001103978.1  zinc finger protein 703 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional exon compared to transcript variant 1. This causes a frame-shift and early translation termination, resulting in a shorter isoform (2) with a different C-terminus compared to isoform 1.
      Source sequence(s)
      AA008919, AC115820, BB609653, BE685996, BE981624, BF323167, BF464968, BQ964921, CD352751, CF582327
      Consensus CDS
      CCDS52531.1
      UniProtKB/TrEMBL
      E9PXD8
      Related
      ENSMUSP00000132801.2, ENSMUST00000127097.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      27467364..27471490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CL69.1 GenPept UniProtKB/Swiss-Prot:P0CL69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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