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    Naa35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit [ Mus musculus (house mouse) ]

    Gene ID: 78689, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Naa35provided by MGI
    Official Full Name
    N(alpha)-acetyltransferase 35, NatC auxiliary subunitprovided by MGI
    Primary source
    MGI:MGI:1925939
    See related
    Ensembl:ENSMUSG00000021555 AllianceGenome:MGI:1925939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mak10; A330021G12Rik; A330027C19Rik; C030004C14Rik
    Summary
    Involved in smooth muscle cell proliferation. Located in cytoplasm. Is expressed in embryo. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 22.3), CNS E11.5 (RPKM 21.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 B2; 13 31.87 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (59733147..59782612)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (59585333..59634798)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_34711 Neighboring gene RIKEN cDNA A230056J06 gene Neighboring gene STARR-seq mESC enhancer starr_34713 Neighboring gene STARR-seq mESC enhancer starr_34715 Neighboring gene STARR-seq mESC enhancer starr_34717 Neighboring gene golgi membrane protein 1 Neighboring gene STARR-seq mESC enhancer starr_34719 Neighboring gene RIKEN cDNA 4921517D22 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Wenzlau JM, et al. Circ Res, 2006 Mar 31. PMID 16484612
    2. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-terminal protein amino acid acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 35, NatC auxiliary subunit
    Names
    MAK10 homolog, amino-acid N-acetyltransferase subunit
    Nalpha acetyltransferase 35
    embryonic growth-associated protein
    protein MAK10 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384120.1 → NP_001371049.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC134869, AC135469
      UniProtKB/Swiss-Prot
      Q05CD3, Q6PHQ8, Q8BYJ9, Q8K3H2
      Conserved Domains (1) summary
      pfam04112
      Location:46 → 181
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    2. NM_001384121.1 → NP_001371050.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134869, AC135469
      Conserved Domains (1) summary
      pfam04112
      Location:46 → 181
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    3. NM_030153.2 → NP_084429.2  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform 1

      See identical proteins and their annotated locations for NP_084429.2

      Status: VALIDATED

      Source sequence(s)
      BC056435, BY100294
      Consensus CDS
      CCDS26575.1
      UniProtKB/Swiss-Prot
      Q05CD3, Q6PHQ8, Q8BYJ9, Q8K3H2
      Related
      ENSMUSP00000022038.8, ENSMUST00000022038.15
      Conserved Domains (1) summary
      pfam04112
      Location:46 → 181
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    RNA

    1. NR_168734.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC134869, AC135469

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      59733147..59782612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247467.2 → XP_030103327.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

      Conserved Domains (1) summary
      pfam04112
      Location:189 → 324
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    2. XM_036158225.1 → XP_036014118.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

      Conserved Domains (1) summary
      pfam04112
      Location:189 → 324
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    RNA

    1. XR_004938075.1 RNA Sequence

    2. XR_004938076.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PHQ8.1 GenPept UniProtKB/Swiss-Prot:Q6PHQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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