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    Csmd1 CUB and Sushi multiple domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 94109, updated on 7-Apr-2024

    Summary

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    Official Symbol
    Csmd1provided by MGI
    Official Full Name
    CUB and Sushi multiple domains 1provided by MGI
    Primary source
    MGI:MGI:2137383
    See related
    Ensembl:ENSMUSG00000060924 AllianceGenome:MGI:2137383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1890; B930082H09
    Summary
    Acts upstream of or within several processes, including learning or memory; mammary gland branching involved in pregnancy; and reproductive structure development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain; cerebral cortex; dorsal root ganglion; main olfactory bulb; and spinal cord. Used to study schizophrenia. Orthologous to human CSMD1 (CUB and Sushi multiple domains 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 2.0), frontal lobe adult (RPKM 1.5) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1- A1.3; 8 8.38 cM
    Exon count:
    71
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (15942538..17586908, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (15892538..17535385, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20808 Neighboring gene STARR-seq mESC enhancer starr_20809 Neighboring gene STARR-seq mESC enhancer starr_20810 Neighboring gene predicted gene, 46033 Neighboring gene STARR-seq mESC enhancer starr_20813 Neighboring gene STARR-seq mESC enhancer starr_20814 Neighboring gene chromobox 1 pseudogene Neighboring gene predicted gene, 46073 Neighboring gene microRNA 3106 Neighboring gene predicted gene, 53402 Neighboring gene STARR-seq mESC enhancer starr_20815 Neighboring gene predicted gene 16347 Neighboring gene predicted gene, 18319 Neighboring gene predicted gene, 25278 Neighboring gene STARR-seq mESC enhancer starr_20817 Neighboring gene STARR-seq mESC enhancer starr_20818 Neighboring gene STARR-seq mESC enhancer starr_20819 Neighboring gene predicted gene, 39136 Neighboring gene STARR-seq mESC enhancer starr_20820 Neighboring gene STARR-seq mESC enhancer starr_20821 Neighboring gene STARR-seq mESC enhancer starr_20822 Neighboring gene predicted gene, 39137 Neighboring gene STARR-seq mESC enhancer starr_20825 Neighboring gene STARR-seq mESC enhancer starr_20828 Neighboring gene STARR-seq mESC enhancer starr_20829 Neighboring gene heat shock protein 1 (chaperonin) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Altered CSMD1 Expression Alters Cocaine-Conditioned Place Preference: Mutual Support for a Complex Locus from Human and Mouse Models. Drgonova J, et al. PLoS One, 2015. PMID 26171607, Free PMC Article
    2. Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant mice. Distler MG, et al. PLoS One, 2012. PMID 23284669, Free PMC Article
    3. Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1. Steen VM, et al. PLoS One, 2013. PMID 24244513, Free PMC Article
    4. Transcript map of the 8p23 putative tumor suppressor region. Sun PC, et al. Genomics, 2001 Jul. PMID 11472063
    5. Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility. Lee AS, et al. Nat Commun, 2019 Oct 11. PMID 31604923, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas.
      Title: Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced neuroinflammation in gliomas.
    2. effect of deleting CSMD1 on mouse behavior
      Title: Assessment of behaviors modeling aspects of schizophrenia in Csmd1 mutant mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (5) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1890

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within conditioned place preference IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland branching involved in pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oviduct epithelium development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within startle response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CUB and sushi domain-containing protein 1
    Names
    CUB and sushi multiple domains protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053171.2 → NP_444401.2  CUB and sushi domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_444401.2

      Status: VALIDATED

      Source sequence(s)
      AC101229, AC154107, AK081081, AK134585, AK220429, AY017475
      Consensus CDS
      CCDS40244.1
      UniProtKB/Swiss-Prot
      E9QK23, Q8BUV1, Q8BYQ3, Q923L3
      Related
      ENSMUSP00000080751.7, ENSMUST00000082104.7
      Conserved Domains (5) summary
      cd00033
      Location:2680 → 2734
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:2087 → 2142
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:2619 → 2855
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:758 → 865
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:2978 → 3032
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      15942538..17586908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508931.5 → XP_006508994.2  CUB and sushi domain-containing protein 1 isoform X2

      Conserved Domains (4) summary
      cd00033
      Location:563 → 617
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:2123 → 2178
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:2655 → 2891
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:794 → 901
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    2. XM_036154398.1 → XP_036010291.1  CUB and sushi domain-containing protein 1 isoform X1

      Conserved Domains (4) summary
      cd00033
      Location:563 → 617
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:2123 → 2178
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:2655 → 2891
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:794 → 901
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    3. XM_030243874.1 → XP_030099734.1  CUB and sushi domain-containing protein 1 isoform X4

      Conserved Domains (6) summary
      cd00033
      Location:1681 → 1734
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:909 → 964
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:1441 → 1677
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:273 → 378
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:1080 → 1137
      Sushi; Sushi repeat (SCR repeat)
      cl00049
      Location:4 → 33
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    4. XM_036154399.1 → XP_036010292.1  CUB and sushi domain-containing protein 1 isoform X3

      Conserved Domains (4) summary
      cd00033
      Location:563 → 617
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:2123 → 2178
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:2488 → 2653
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:794 → 901
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923L3.2 GenPept UniProtKB/Swiss-Prot:Q923L3

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