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    Amdhd1 amidohydrolase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 71761, updated on 23-Jun-2021

    Summary

    Official Symbol
    Amdhd1provided by MGI
    Official Full Name
    amidohydrolase domain containing 1provided by MGI
    Primary source
    MGI:MGI:1919011
    See related
    Ensembl:ENSMUSG00000015890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300019J08Rik
    Expression
    Biased expression in liver adult (RPKM 83.5) and liver E18 (RPKM 10.1) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Amdhd1 in Genome Data Viewer
    Location:
    10; 10 C2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93359200..93375973, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93523338..93540111, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (92986083..93002778, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leukotriene A4 hydrolase Neighboring gene histidine ammonia lyase Neighboring gene coiled-coil domain containing 38 Neighboring gene RIKEN cDNA 4933408J17 gene Neighboring gene small nuclear ribonucleoprotein polypeptide F

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC148226

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides IEA
    Inferred from Electronic Annotation
    more info
     
    enables imidazolonepropionase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in histidine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histidine catabolic process to glutamate and formamide IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within histidine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable imidazolonepropionase
    Names
    amidohydrolase domain-containing protein 1
    NP_082184.1
    XP_006514230.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027908.1NP_082184.1  probable imidazolonepropionase

      See identical proteins and their annotated locations for NP_082184.1

      Status: VALIDATED

      Source sequence(s)
      AK005066, AK090143, BB856590
      Consensus CDS
      CCDS48671.1
      UniProtKB/Swiss-Prot
      Q9DBA8
      Related
      ENSMUSP00000016034.3, ENSMUST00000016034.3
      Conserved Domains (2) summary
      COG1228
      Location:4426
      HutI; Imidazolonepropionase or related amidohydrolase [Secondary metabolites biosynthesis, transport and catabolism]
      cd01296
      Location:43420
      Imidazolone-5PH; Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria, ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93359200..93375973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514167.4XP_006514230.1  probable imidazolonepropionase isoform X1

      Conserved Domains (1) summary
      cl00281
      Location:43345
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
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