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    Zfp420 zinc finger protein 420 [ Mus musculus (house mouse) ]

    Gene ID: 233058, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Zfp420provided by MGI
    Official Full Name
    zinc finger protein 420provided by MGI
    Primary source
    MGI:MGI:2444666
    See related
    Ensembl:ENSMUSG00000058402 AllianceGenome:MGI:2444666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mszf70; mszf59-1; B230119D13; B230312I18Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within blastocyst hatching. Predicted to be active in nucleus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human ZNF420 (zinc finger protein 420). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 3.8), whole brain E14.5 (RPKM 2.7) and 19 other tissues See more
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    Genomic context

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    Location:
    7 B1; 7 17.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29559392..29576727)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29859967..29877302)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18491 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30601028-30601137 Neighboring gene zinc finger protein 790 Neighboring gene zinc finger protein 940 Neighboring gene STARR-positive B cell enhancer ABC_E8836 Neighboring gene STARR-positive B cell enhancer ABC_E10434 Neighboring gene STARR-seq mESC enhancer starr_18494 Neighboring gene zinc finger protein 27 Neighboring gene STARR-positive B cell enhancer ABC_E9288 Neighboring gene microRNA 7668 Neighboring gene zinc finger protein 383

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 420

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364618.1 → NP_001351547.1  zinc finger protein 420

      Status: VALIDATED

      Source sequence(s)
      AC149283, AK045435, AK045821, BY069284, BY259697, CD807409
      Consensus CDS
      CCDS52175.1
      UniProtKB/TrEMBL
      Q7TMN8
      Related
      ENSMUSP00000056077.7, ENSMUST00000057652.7
      Conserved Domains (3) summary
      COG5048
      Location:23 → 462
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283 → 303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:519 → 544
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001364619.1 → NP_001351548.1  zinc finger protein 420

      Status: VALIDATED

      Source sequence(s)
      AC149283, AK045435, AK045821, BY069284, BY259697, CD807409
      Consensus CDS
      CCDS52175.1
      UniProtKB/TrEMBL
      Q7TMN8
      Related
      ENSMUST00000145952.2
      Conserved Domains (3) summary
      COG5048
      Location:23 → 462
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283 → 303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:519 → 544
      zf-H2C2_2; Zinc-finger double domain

    3. NM_172740.2 → NP_766328.2  zinc finger protein 420

      See identical proteins and their annotated locations for NP_766328.2

      Status: VALIDATED

      Source sequence(s)
      AC149283
      Consensus CDS
      CCDS52175.1
      UniProtKB/TrEMBL
      Q7TMN8
      Related
      ENSMUSP00000074417.7, ENSMUST00000074876.13
      Conserved Domains (3) summary
      COG5048
      Location:23 → 462
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283 → 303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:519 → 544
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29559392..29576727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250536.2 → XP_011248838.1  zinc finger protein 420 isoform X1

      See identical proteins and their annotated locations for XP_011248838.1

      UniProtKB/TrEMBL
      Q7TMN8
      Conserved Domains (3) summary
      COG5048
      Location:23 → 462
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283 → 303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:519 → 544
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036152954.1 → XP_036008847.1  zinc finger protein 420 isoform X2

    3. XM_036152956.1 → XP_036008849.1  zinc finger protein 420 isoform X2

    4. XM_036152955.1 → XP_036008848.1  zinc finger protein 420 isoform X2

    5. XM_036152953.1 → XP_036008846.1  zinc finger protein 420 isoform X2

    6. XM_011250538.1 → XP_011248840.1  zinc finger protein 420 isoform X1

      See identical proteins and their annotated locations for XP_011248840.1

      UniProtKB/TrEMBL
      Q7TMN8
      Conserved Domains (3) summary
      COG5048
      Location:23 → 462
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:283 → 303
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:519 → 544
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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