Nmrk1 nicotinamide riboside kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nmrk1provided by MGI
Official Full Name: nicotinamide riboside kinase 1provided by MGI
Primary source: MGI:MGI:2147434
See related: Ensembl:ENSMUSG00000037847 AllianceGenome:MGI:2147434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nrk1; D630020N23Rik
Summary: Predicted to enable ribosylnicotinamide kinase activity and ribosylnicotinate kinase activity. Predicted to act upstream of or within phosphorylation and pyridine nucleotide biosynthetic process. Predicted to be active in cytoplasm. Is expressed in cochlea; ear; inner ear; nervous system; and vestibulo-cochlear ganglion. Orthologous to human NMRK1 (nicotinamide riboside kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 16.9), placenta adult (RPKM 6.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 13.17 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (18609380..18629555)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (18632016..18652428)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic beta-cell failure.
Title: Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure.
NRK1 KO myotubes revealed redundancy in the NRK1/2 dependent metabolism of nicotinamide riboside to NAD+.
Title: Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.
adenoviral delivery of NRK1 in diet- and age-induced mice elevates hepatic NAD(+) levels, reduces hepatic steatosis, and improves glucose tolerance and insulin sensitivity.
Title: Overexpression of NRK1 ameliorates diet- and age-induced hepatic steatosis and insulin resistance.
nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous nicotinamide riboside and nicotinamide mononucleotide for NAD(+) synthesis.
Title: NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables ribosylnicotinamide kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosylnicotinamide kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosylnicotinate kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyridine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nicotinamide riboside kinase 1

Names: NRK 1; RNK 1; nicotinic acid riboside kinase 1; nmR-K 1; ribosylnicotinamide kinase 1; ribosylnicotinic acid kinase 1

NP_663472.1

EC 2.7.1.173

EC 2.7.1.22

XP_011245527.1

EC 2.7.1.173

EC 2.7.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145497.2 → NP_663472.1 nicotinamide riboside kinase 1

See identical proteins and their annotated locations for NP_663472.1

Status: VALIDATED

Source sequence(s)

AC134906

Consensus CDS

CCDS37931.1

UniProtKB/Swiss-Prot

Q3TDW3, Q91W63

UniProtKB/TrEMBL

A0A498WGT1

Related

ENSMUSP00000158342.2, ENSMUST00000237347.2

Conserved Domains (1) summary

cd02024
Location:5 → 158

NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

18609380..18629555

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247225.3 → XP_011245527.1 nicotinamide riboside kinase 1 isoform X1

Conserved Domains (1) summary

cl17190
Location:1 → 96

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...