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    Cox5a cytochrome c oxidase subunit 5A [ Mus musculus (house mouse) ]

    Gene ID: 12858, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cox5aprovided by MGI
    Official Full Name
    cytochrome c oxidase subunit 5Aprovided by MGI
    Primary source
    MGI:MGI:88474
    See related
    Ensembl:ENSMUSG00000000088 AllianceGenome:MGI:88474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CcOX
    Summary
    Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of mitochondrial respiratory chain complex IV. Is expressed in several structures, including alimentary system; hindlimb musculature; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in duodenum adult (RPKM 1236.7), stomach adult (RPKM 854.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cox5a in Genome Data Viewer
    Location:
    9 B; 9 31.05 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57423012..57439710)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57517328..57532427)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51707 Neighboring gene STARR-seq mESC enhancer starr_24237 Neighboring gene STARR-seq mESC enhancer starr_24239 Neighboring gene ribonuclease P/MRP 25 subunit Neighboring gene STARR-positive B cell enhancer ABC_E11408 Neighboring gene family with sequence similarity 219, member B Neighboring gene mannose phosphate isomerase Neighboring gene STARR-positive B cell enhancer ABC_E3834 Neighboring gene STARR-positive B cell enhancer ABC_E3835 Neighboring gene secretory carrier membrane protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome. Costa AC, et al. Neurosci Lett, 2005 Jul 15. PMID 15925111
    2. Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury. Prabu SK, et al. J Biol Chem, 2006 Jan 27. PMID 16303765, Free PMC Article
    3. Mitochondrial type I nitric oxide synthase physically interacts with cytochrome c oxidase. Persichini T, et al. Neurosci Lett, 2005 Aug 26. PMID 15923083
    4. Amino acid replacement is rapid in primates for the mature polypeptides of COX subunits, but not for their targeting presequences. Schmidt TR, et al. Gene, 2002 Mar 6. PMID 11943455
    5. Isolation and sequence of the structural gene for cytochrome c oxidase subunit VI from Saccharomyces cerevisiae. Wright RM, et al. J Biol Chem, 1984 Dec 25. PMID 6210289

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCN2B could play an important role in the aging-related cognitive deterioration, which is associated with the regulations of COX5A and FGF-2.
      Title: Sodium Channel Voltage-Gated Beta 2 Plays a Vital Role in Brain Aging Associated with Synaptic Plasticity and Expression of COX5A and FGF-2.
    2. gene expression of the Cox subunits, Cox5a, 5b, and 6b1 is not required for embryo developmental events up to the blastocyst stage
      Title: Gene expression of cox5a, 5b, or 6b1 and their roles in preimplantation mouse embryos.
    3. Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury
      Title: Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytochrome-c oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex IV ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myelin sheath HDA PubMed 

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 5A, mitochondrial
    Names
    cytochrome c oxidase polypeptide Va
    cytochrome c oxidase subunit Va
    NP_031773.2
    XP_030099894.1
    XP_036010484.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007747.2 → NP_031773.2  cytochrome c oxidase subunit 5A, mitochondrial precursor

      See identical proteins and their annotated locations for NP_031773.2

      Status: VALIDATED

      Source sequence(s)
      AK018723, BY259203, CO044753
      Consensus CDS
      CCDS23223.1
      UniProtKB/Swiss-Prot
      P12787, Q9D2W1
      Related
      ENSMUSP00000000090.7, ENSMUST00000000090.8
      Conserved Domains (1) summary
      cd00923
      Location:41 → 142
      Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57423012..57439710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244034.2 → XP_030099894.1  cytochrome c oxidase subunit 5A, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P12787, Q9D2W1
      Conserved Domains (1) summary
      cd00923
      Location:41 → 142
      Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. XM_036154591.1 → XP_036010484.1  cytochrome c oxidase subunit 5A, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      P12787, Q9D2W1
      Conserved Domains (1) summary
      cd00923
      Location:41 → 142
      Cyt_c_Oxidase_Va; Cytochrome c oxidase subunit Va. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12787.2 GenPept UniProtKB/Swiss-Prot:P12787

    Gene LinkOut

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