Dkk3 dickkopf WNT signaling pathway inhibitor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dkk3provided by MGI
Official Full Name: dickkopf WNT signaling pathway inhibitor 3provided by MGI
Primary source: MGI:MGI:1354952
See related: Ensembl:ENSMUSG00000030772 AllianceGenome:MGI:1354952
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: dkk-3; mDkk-3
Summary: Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of cellular biosynthetic process. Predicted to act upstream of or within Wnt signaling pathway. Located in extracellular space. Is expressed in several structures, including brain; cardiovascular system; eye; limb; and tooth. Orthologous to human DKK3 (dickkopf WNT signaling pathway inhibitor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 37.0), bladder adult (RPKM 29.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F1; 7 58.74 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (111715226..111758689, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (112116019..112159482, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.
Title: Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.
A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.
Title: A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis.
Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
Title: Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats.
Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis.
Title: Dickkopf 3: a Novel Target Gene of miR-25-3p in Promoting Fibrosis-Related Gene Expression in Myocardial Fibrosis.
Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
Title: Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration.
Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse.
Title: Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse.
Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland.
Title: Dkk3/REIC, an N-glycosylated Protein, Is a Physiological Endoplasmic Reticulum Stress Inducer in the Mouse Adrenal Gland.
DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage.
Title: DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage.
Dkk3 maintains the integrity of secreting vesicles in mouse adrenal medulla by regulating the expression of chromogranin A and neuropeptide Y
Title: Dickkopf3 (Dkk3) is required for maintaining the integrity of secretory vesicles in the mouse adrenal medulla.
Dkk3 binds to CXCR7 and enhances vascular progenitor cells cell migration and vascular regeneration.
Title: Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

Dkk3 (e-PCR), detects polymorphism
- UniSTS:471823

Dkk3 (e-PCR), detects polymorphism
- UniSTS:508433

Dkk3 (e-PCR), detects polymorphism
- UniSTS:527122

Dkk3 (e-PCR), detects polymorphism
- UniSTS:508434

AI713502 (e-PCR)
- UniSTS:245060

Dkk3 (e-PCR), detects polymorphism
- UniSTS:472903

Dkk3 (e-PCR), detects polymorphism
- UniSTS:277879

C87148 (e-PCR)
- UniSTS:179620

AW061014 (e-PCR)
- UniSTS:179625

Dkk3 (e-PCR), detects polymorphism
- UniSTS:528043

Dkk3 (e-PCR), detects polymorphism
- UniSTS:506849

NoName (e-PCR)
- UniSTS:235751

NoName (e-PCR)
- UniSTS:235752

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables co-receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: dickkopf-related protein 3

Names: dickkopf homolog 3; dickkopf-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360257.1 → NP_001347186.1 dickkopf-related protein 3 isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

AC122343, FO707532
NM_001360260.1 → NP_001347189.1 dickkopf-related protein 3 isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC122343, AC166834

Consensus CDS

CCDS21752.1

UniProtKB/Swiss-Prot

Q9QUN9

Conserved Domains (1) summary

pfam04706
Location:147 → 196

Dickkopf_N; Dickkopf N-terminal cysteine-rich region
NM_001360261.1 → NP_001347190.1 dickkopf-related protein 3 isoform c precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.

Source sequence(s)

AC122343, AC166834

Conserved Domains (1) summary

pfam04706
Location:119 → 168

Dickkopf_N; Dickkopf N-terminal cysteine-rich region
NM_015814.3 → NP_056629.1 dickkopf-related protein 3 isoform b precursor

See identical proteins and their annotated locations for NP_056629.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC166834, AK004853

Consensus CDS

CCDS21752.1

UniProtKB/Swiss-Prot

Q9QUN9

Related

ENSMUSP00000033036.6, ENSMUST00000033036.7

Conserved Domains (1) summary

pfam04706
Location:147 → 196

Dickkopf_N; Dickkopf N-terminal cysteine-rich region