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    Pbld2 phenazine biosynthesis-like protein domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 67307, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pbld2provided by MGI
    Official Full Name
    phenazine biosynthesis-like protein domain containing 2provided by MGI
    Primary source
    MGI:MGI:1914557
    See related
    Ensembl:ENSMUSG00000020072 AllianceGenome:MGI:1914557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mawbp; 3110049J23Rik
    Summary
    Predicted to enable identical protein binding activity and isomerase activity. Predicted to be involved in maintenance of gastrointestinal epithelium; negative regulation of SMAD protein signal transduction; and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in pancreas epithelium and renal calyx. Orthologous to human PBLD (phenazine biosynthesis like protein domain containing). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 25.9), large intestine adult (RPKM 8.4) and 6 other tissues See more
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    Genomic context

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    Location:
    10 B4; 10 32.52 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62858319..62894592)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63024053..63058813)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62409633-62409742 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene RUN and FYVE domain-containing 2 Neighboring gene STARR-seq mESC enhancer starr_26916 Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene predicted gene 16143 Neighboring gene phenazine biosynthesis-like protein domain containing 1 Neighboring gene atonal bHLH transcription factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of gastrointestinal epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within_positive_effect negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phenazine biosynthesis-like domain-containing protein 2
    Names
    MAWD binding protein homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405744.1 → NP_001392673.1  phenazine biosynthesis-like domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AC113107
      UniProtKB/Swiss-Prot
      Q9CXN7, Q9D2W4

    2. NM_001405745.1 → NP_001392674.1  phenazine biosynthesis-like domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AC113107
      UniProtKB/Swiss-Prot
      Q9CXN7, Q9D2W4

    3. NM_001405746.1 → NP_001392675.1  phenazine biosynthesis-like domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AC113107
      UniProtKB/Swiss-Prot
      Q9CXN7, Q9D2W4

    4. NM_026085.3 → NP_080361.1  phenazine biosynthesis-like domain-containing protein 2

      See identical proteins and their annotated locations for NP_080361.1

      Status: VALIDATED

      Source sequence(s)
      AC113107
      Consensus CDS
      CCDS23894.1
      UniProtKB/Swiss-Prot
      Q9CXN7, Q9D2W4
      UniProtKB/TrEMBL
      K3W4L7
      Related
      ENSMUSP00000020262.5, ENSMUST00000020262.5
      Conserved Domains (1) summary
      cl29427
      Location:9 → 284
      PhzC-PhzF; Phenazine biosynthesis-like protein

    RNA

    1. NR_175965.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113107

    2. NR_175966.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113107

    3. NR_175967.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC113107

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62858319..62894592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513983.2 → XP_006514046.1  phenazine biosynthesis-like domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      K3W4L7
      Conserved Domains (1) summary
      cl29427
      Location:46 → 321
      PhzC-PhzF; Phenazine biosynthesis-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXN7.1 GenPept UniProtKB/Swiss-Prot:Q9CXN7

    Gene LinkOut

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