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    Cep85 centrosomal protein 85 [ Mus musculus (house mouse) ]

    Gene ID: 70012, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cep85provided by MGI
    Official Full Name
    centrosomal protein 85provided by MGI
    Primary source
    MGI:MGI:1917262
    See related
    Ensembl:ENSMUSG00000037443 AllianceGenome:MGI:1917262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc21; 2410030J07Rik
    Summary
    Predicted to be involved in negative regulation of protein kinase activity and regulation of mitotic centrosome separation. Predicted to act upstream of or within chromosome segregation. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and nucleolus. Predicted to be active in centrosome. Orthologous to human CEP85 (centrosomal protein 85). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 25.3), thymus adult (RPKM 18.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.3; 4 66.5 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133857169..133914420, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134129858..134187085, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10264 Neighboring gene UBX domain protein 11 Neighboring gene STARR-seq mESC enhancer starr_11667 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133677585-133677803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133680177-133680360 Neighboring gene SH3 domain binding glutamic acid-rich protein-like 3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:133715471-133715771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:133742713-133742822 Neighboring gene STARR-positive B cell enhancer ABC_E843 Neighboring gene zona pellucida like domain containing 2 Neighboring gene cation channel, sperm associated 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. Chen C, et al. J Cell Sci, 2015 Sep 1. PMID 26220856, Free PMC Article
    2. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cep85 is a bona fide Nek2A-binding partner that surrounds the proximal ends of centrioles where it cooperates with PP1gamma (also known as PPP1CC) to antagonize Nek2A
      Title: Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 85 kDa
    Names
    coiled-coil domain containing 21
    coiled-coil domain-containing protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144527.3 → NP_653110.3  centrosomal protein of 85 kDa

      See identical proteins and their annotated locations for NP_653110.3

      Status: VALIDATED

      Source sequence(s)
      AK085545, AK141103, AV301648, AW123366, BY250554
      Consensus CDS
      CCDS18765.1
      UniProtKB/Swiss-Prot
      Q8BMK0, Q8BUF1, Q8K0E6
      UniProtKB/TrEMBL
      A2A9K3
      Related
      ENSMUSP00000039889.6, ENSMUST00000040271.12
      Conserved Domains (1) summary
      COG1196
      Location:381 → 652
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133857169..133914420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164407.1 → XP_036020300.1  centrosomal protein of 85 kDa isoform X1

      UniProtKB/Swiss-Prot
      Q8BMK0, Q8BUF1, Q8K0E6
      UniProtKB/TrEMBL
      A2A9K3
      Conserved Domains (1) summary
      COG1196
      Location:381 → 652
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_036164408.1 → XP_036020301.1  centrosomal protein of 85 kDa isoform X2

      UniProtKB/TrEMBL
      A2A9K3
      Conserved Domains (1) summary
      COG1196
      Location:330 → 601
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_036164409.1 → XP_036020302.1  centrosomal protein of 85 kDa isoform X3

      UniProtKB/TrEMBL
      A2A9K3
      Conserved Domains (1) summary
      COG1196
      Location:318 → 589
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMK0.2 GenPept UniProtKB/Swiss-Prot:Q8BMK0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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