Pcdh20 protocadherin 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcdh20provided by MGI
Official Full Name: protocadherin 20provided by MGI
Primary source: MGI:MGI:2443376
See related: Ensembl:ENSMUSG00000050505 AllianceGenome:MGI:2443376
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pcdh13; C630015B17Rik
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in cell adhesion in the nervous system and has been shown to be specifically expressed in newly differentiated olfactory sensory neurons and their axons during development. In adult mice, the expression of this protein in the olfactory system is more restricted but shows a gender difference with higher expression in the male than in the female. [provided by RefSeq, Sep 2009]
Expression: Biased expression in frontal lobe adult (RPKM 3.1), cortex adult (RPKM 2.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E1; 14 44.43 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (88702183..88708832, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (88464743..88471396, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of protocadherin-20 in mouse taste buds.
Title: Expression of protocadherin-20 in mouse taste buds.
The gender difference in PCDH20 expression may reflect olfactory receptor expression differences for gender-specific social discrimination
Title: Olfactory sensory neuron-specific and sexually dimorphic expression of protocadherin 20.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protocadherin-20

Names: protocadherin 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178685.5 → NP_848800.3 protocadherin-20 precursor

See identical proteins and their annotated locations for NP_848800.3

Status: REVIEWED

Source sequence(s)

AC164553, AK083114, BC079605

Consensus CDS

CCDS27306.1

UniProtKB/Swiss-Prot

E9QK76, Q8BIV2, Q8BIZ0

UniProtKB/TrEMBL

B2RWR1

Related

ENSMUSP00000054774.6, ENSMUST00000061628.7

Conserved Domains (3) summary

cd11304
Location:541 → 636

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:70 → 153

Cadherin_2; Cadherin-like

cl29226
Location:490 → 534

Cadherin; Cadherin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

88702183..88708832 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158574.1 → XP_036014467.1 protocadherin-20 isoform X1

UniProtKB/Swiss-Prot

E9QK76, Q8BIV2, Q8BIZ0

UniProtKB/TrEMBL

B2RWR1

Related

ENSMUSP00000141860.2, ENSMUST00000192557.2

Conserved Domains (3) summary

cd11304
Location:541 → 636

Cadherin_repeat; Cadherin tandem repeat domain

pfam08266
Location:70 → 153

Cadherin_2; Cadherin-like

cl29226
Location:490 → 534

Cadherin; Cadherin domain