Nfe2 nuclear factor, erythroid derived 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfe2provided by MGI
Official Full Name: nuclear factor, erythroid derived 2provided by MGI
Primary source: MGI:MGI:97308
See related: Ensembl:ENSMUSG00000058794 AllianceGenome:MGI:97308
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p45; NF-E2; p45NFE2; p45nf-e2; NF-E2/P45
Summary: Predicted to enable several functions, including WW domain binding activity; identical protein binding activity; and protein N-terminus binding activity. Predicted to contribute to cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and negative regulation of syncytium formation by plasma membrane fusion. Located in nucleus. Is expressed in several structures, including dorsal aorta; eye; genitourinary system; limb; and yolk sac. Orthologous to human NFE2 (nuclear factor, erythroid 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14.5 (RPKM 63.0), liver E14 (RPKM 51.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F3; 15 58.62 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (103156640..103166809, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (103248212..103258403, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2[V617F] mutated cells.
Title: The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells.
mutations in NFE2 predispose to the acquisition of secondary changes promoting the development of myelosarcoma and/or AML
Title: Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations.
We detected that cigarette smoke significantly increased p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our results indicate that p45 NFE2 expression is induced by exposure to cigarette smoke, has a cytoprotective activity against cell injury, and its downregulation in human primary ATII cells may contribute to emphysema pathogenesis
Title: The cytoprotective role of DJ-1 and p45 NFE2 against human primary alveolar type II cell injury and emphysema.
Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1, FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.
Title: NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes.
Under the obese condition, activation of the hepatic NFE2/miR-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A-ATP-Akt signaling pathway.
Title: NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway.
results suggest that Nrf2 deficiency induced by HFD promoted hepatic fatty acid metabolism disorder by altering 18-carbon and 22-carbon fatty acid composition
Title: NF-E2-related factor 2 deletion facilitates hepatic fatty acids metabolism disorder induced by high-fat diet via regulating related genes in mice.
A novel murine model may excellently describe the deleterious impact of sustained chronic NF-E2 overexpression during uncontrolled chronic inflammation upon the hematopoietic system--the development of clonal myeloproliferation.
Title: A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis?
Although none of the parameters measured were different between the NF-E2 deficient and control mice, an increase in calcium (21%) and an increase in the mineral/matrix ratio (32%) was observed in GATA-1 deficient mice.
Title: The effects of GATA-1 and NF-E2 deficiency on bone biomechanical, biochemical, and mineral properties.
By activating genes in megakaryocytes that mediate platelet production and function, NF-E2 p45 determines the quantity and quality of platelets.
Title: NF-E2 p45 is important for establishing normal function of platelets.
maintaining expression of intestinal epithelial cell prohibitin reduces the severity of inflammation and increases colonic levels of the antioxidants HO-1 and NQO-1 via a mechanism independent of Nfe2
Title: Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables WW domain binding	ISO Inferred from Sequence Orthology more info
contributes_to cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of syncytium formation by plasma membrane fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of syncytium formation by plasma membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-lysine acetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of syncytium formation by plasma membrane fusion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of syncytium formation by plasma membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor NF-E2 45 kDa subunit

Names: leucine zipper protein NF-E2; nuclear factor, erythroid derived 2, 45 kDa; nuclear factor, erythroid-derived 2 45 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302338.2 → NP_001289267.1 transcription factor NF-E2 45 kDa subunit

See identical proteins and their annotated locations for NP_001289267.1

Status: VALIDATED

Source sequence(s)

AC164069

Consensus CDS

CCDS27900.1

UniProtKB/Swiss-Prot

Q07279, Q6P6K5

UniProtKB/TrEMBL

A0A0R4J0Y5

Related

ENSMUSP00000122476.2, ENSMUST00000149111.8

Conserved Domains (1) summary

cd14720
Location:263 → 330

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_001302339.2 → NP_001289268.1 transcription factor NF-E2 45 kDa subunit

See identical proteins and their annotated locations for NP_001289268.1

Status: VALIDATED

Source sequence(s)

AC164069

Consensus CDS

CCDS27900.1

UniProtKB/Swiss-Prot

Q07279, Q6P6K5

UniProtKB/TrEMBL

A0A0R4J0Y5

Conserved Domains (1) summary

cd14720
Location:263 → 330

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_001302340.2 → NP_001289269.1 transcription factor NF-E2 45 kDa subunit

See identical proteins and their annotated locations for NP_001289269.1

Status: VALIDATED

Source sequence(s)

AC164069

Consensus CDS

CCDS27900.1

UniProtKB/Swiss-Prot

Q07279, Q6P6K5

UniProtKB/TrEMBL

A0A0R4J0Y5

Conserved Domains (1) summary

cd14720
Location:263 → 330

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_001302341.2 → NP_001289270.1 transcription factor NF-E2 45 kDa subunit

See identical proteins and their annotated locations for NP_001289270.1

Status: VALIDATED

Source sequence(s)

AC164069

Consensus CDS

CCDS27900.1

UniProtKB/Swiss-Prot

Q07279, Q6P6K5

UniProtKB/TrEMBL

A0A0R4J0Y5

Conserved Domains (1) summary

cd14720
Location:263 → 330

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_001302343.2 → NP_001289272.1 transcription factor NF-E2 45 kDa subunit

See identical proteins and their annotated locations for NP_001289272.1

Status: VALIDATED

Source sequence(s)

AC164069

Consensus CDS

CCDS27900.1

UniProtKB/Swiss-Prot

Q07279, Q6P6K5

UniProtKB/TrEMBL

A0A0R4J0Y5

Conserved Domains (1) summary

cd14720
Location:263 → 330

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
NM_001400376.1 → NP_001387305.1 transcription factor NF-E2 45 kDa subunit

Status: VALIDATED

Source sequence(s)

AC164069

UniProtKB/TrEMBL

A0A0R4J0Y5

Related

ENSMUSP00000114160.2, ENSMUST00000156927.8
NM_008685.4 → NP_032711.2 transcription factor NF-E2 45 kDa subunit

See identical proteins and their annotated locations for NP_032711.2

Status: VALIDATED

Source sequence(s)

AC164069

Consensus CDS

CCDS27900.1

UniProtKB/Swiss-Prot

Q07279, Q6P6K5

UniProtKB/TrEMBL

A0A0R4J0Y5

Related

ENSMUSP00000074684.7, ENSMUST00000075192.13

Conserved Domains (1) summary

cd14720
Location:263 → 330

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

103156640..103166809 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520573.4 → XP_006520636.1 transcription factor NF-E2 45 kDa subunit isoform X2

See identical proteins and their annotated locations for XP_006520636.1

UniProtKB/Swiss-Prot

Q07279, Q6P6K5

UniProtKB/TrEMBL

A0A0R4J0Y5

Conserved Domains (1) summary

cd14720
Location:263 → 330

bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain