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    Tmem209 transmembrane protein 209 [ Mus musculus (house mouse) ]

    Gene ID: 72649, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Tmem209provided by MGI
    Official Full Name
    transmembrane protein 209provided by MGI
    Primary source
    MGI:MGI:1919899
    See related
    Ensembl:ENSMUSG00000029782 AllianceGenome:MGI:1919899
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700094F01Rik
    Summary
    Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in inferior colliculus; midbrain; and midbrain ventricular layer. Orthologous to human TMEM209 (transmembrane protein 209). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.1), placenta adult (RPKM 7.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A3.3; 6 12.52 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30480806..30509786, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30481022..30509787, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:30351601-30351833 Neighboring gene kelch domain containing 10 Neighboring gene RIKEN cDNA 1700012C14 gene Neighboring gene STARR-seq mESC enhancer starr_15468 Neighboring gene serine-rich single-pass membrane protein 1 Neighboring gene predicted gene, 53278 Neighboring gene carboxypeptidase A2, pancreatic

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    2. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 209

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311093.1 → NP_001298022.1  transmembrane protein 209 isoform 2

      See identical proteins and their annotated locations for NP_001298022.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC052187, BC057109, BY780525
      Consensus CDS
      CCDS80511.1
      UniProtKB/TrEMBL
      F8WGT2
      Related
      ENSMUSP00000110810.2, ENSMUST00000115157.8
      Conserved Domains (1) summary
      pfam09786
      Location:5 → 559
      CytochromB561_N; Cytochrome B561, N terminal

    2. NM_001347087.1 → NP_001334016.1  transmembrane protein 209 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC155848
      Consensus CDS
      CCDS85026.1
      UniProtKB/TrEMBL
      D3Z438, Q8C214
      Related
      ENSMUSP00000138232.2, ENSMUST00000151187.8
      Conserved Domains (1) summary
      cl39050
      Location:2 → 402
      BAT2_N; BAT2 N-terminus

    3. NM_178625.4 → NP_848740.3  transmembrane protein 209 isoform 1

      See identical proteins and their annotated locations for NP_848740.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC057109, BY780525
      Consensus CDS
      CCDS19972.1
      UniProtKB/Swiss-Prot
      Q80WQ3, Q8BP02, Q8BRG8, Q8C202, Q8CDY5
      UniProtKB/TrEMBL
      F8WGT2
      Related
      ENSMUSP00000110813.4, ENSMUST00000115160.10
      Conserved Domains (1) summary
      pfam09786
      Location:6 → 560
      CytochromB561_N; Cytochrome B561, N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      30480806..30509786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505172.4 → XP_006505235.1  transmembrane protein 209 isoform X3

      UniProtKB/TrEMBL
      F8WGT2
      Conserved Domains (1) summary
      cl39050
      Location:6 → 516
      BAT2_N; BAT2 N-terminus

    2. XM_017321766.3 → XP_017177255.1  transmembrane protein 209 isoform X4

      UniProtKB/TrEMBL
      D3Z438, Q8C214
      Conserved Domains (1) summary
      cl39050
      Location:2 → 402
      BAT2_N; BAT2 N-terminus

    3. XM_006505170.5 → XP_006505233.2  transmembrane protein 209 isoform X1

      UniProtKB/TrEMBL
      F8WGT2
      Conserved Domains (1) summary
      pfam09786
      Location:5 → 559
      CytochromB561_N; Cytochrome B561, N terminal

    4. XM_006505171.3 → XP_006505234.1  transmembrane protein 209 isoform X2

      UniProtKB/TrEMBL
      F8WGT2
      Conserved Domains (1) summary
      pfam09786
      Location:15 → 569
      CytochromB561_N; Cytochrome B561, N terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BRG8.1 GenPept UniProtKB/Swiss-Prot:Q8BRG8

    Gene LinkOut

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