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    Arhgef5 Rho guanine nucleotide exchange factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 54324, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Arhgef5provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 5provided by MGI
    Primary source
    MGI:MGI:1858952
    See related
    Ensembl:ENSMUSG00000033542 AllianceGenome:MGI:1858952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tim1; 2210412D05Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; myeloid dendritic cell chemotaxis; and positive regulation of podosome assembly. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human ARHGEF5 (Rho guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in large intestine adult (RPKM 16.0), placenta adult (RPKM 11.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 B2.1; 6 21.15 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (43242578..43266250)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (43265644..43289320)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15730 Neighboring gene olfactory receptor family 2 subfamily A member 2 Neighboring gene olfactory receptor family 2 subfamily A member 57 Neighboring gene STARR-seq mESC enhancer starr_15732 Neighboring gene NOBOX oogenesis homeobox Neighboring gene thiamine pyrophosphokinase Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Arhgef5 Binds α-Dystrobrevin 1 and Regulates Neuromuscular Junction Integrity. Bernadzki KM, et al. Front Mol Neurosci, 2020. PMID 32587503, Free PMC Article
    2. A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth. Hamilton AM, et al. Mol Cell Neurosci, 2017 Apr. PMID 28185854, Free PMC Article
    3. Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducing Arc expression. Mandel-Brehm C, et al. Proc Natl Acad Sci U S A, 2015 Apr 21. PMID 25848016, Free PMC Article
    4. Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice. Sell GL, et al. J Clin Invest, 2017 May 1. PMID 28346227, Free PMC Article
    5. Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. Wang Z, et al. J Biol Chem, 2009 Oct 16. PMID 19713215, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RhoA guanine nucleotide exchange factor Arhgef5 regulates immature dendritic cell migration
      Title: Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myeloid dendritic cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of podosome assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 5
    Names
    Rho guanine nucleotide exchange factor (GEF) 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417622.1 → NP_001404551.1  rho guanine nucleotide exchange factor 5

      Status: VALIDATED

      Source sequence(s)
      AC153885, AC158671
      UniProtKB/Swiss-Prot
      E9Q7D5, Q8R172, Q922T1

    2. NM_133674.2 → NP_598435.1  rho guanine nucleotide exchange factor 5

      See identical proteins and their annotated locations for NP_598435.1

      Status: VALIDATED

      Source sequence(s)
      AC153885, AC158671
      Consensus CDS
      CCDS51759.1
      UniProtKB/Swiss-Prot
      E9Q7D5, Q8R172, Q922T1
      Related
      ENSMUSP00000031750.7, ENSMUST00000031750.14
      Conserved Domains (5) summary
      cd11940
      Location:1498 → 1552
      SH3_ARHGEF5_19; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF5 and ARHGEF19
      PHA03247
      Location:398 → 949
      PHA03247; large tegument protein UL36; Provisional
      cd01221
      Location:1362 → 1488
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:1164 → 1340
      RhoGEF; RhoGEF domain
      pfam15441
      Location:1 → 477
      ARHGEF5_35; Rho guanine nucleotide exchange factor 5/35

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      43242578..43266250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q7D5.1 GenPept UniProtKB/Swiss-Prot:E9Q7D5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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