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    Bdh2 3-hydroxybutyrate dehydrogenase, type 2 [ Mus musculus (house mouse) ]

    Gene ID: 69772, updated on 22-Aug-2021

    Summary

    Official Symbol
    Bdh2provided by MGI
    Official Full Name
    3-hydroxybutyrate dehydrogenase, type 2provided by MGI
    Primary source
    MGI:MGI:1917022
    See related
    Ensembl:ENSMUSG00000028167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dhr; Dhrs6; 1810026B04Rik
    Expression
    Biased expression in kidney adult (RPKM 79.3), liver adult (RPKM 4.6) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Bdh2 in Genome Data Viewer
    Location:
    3; 3 G3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (134986982..135010187)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135281221..135304426)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (134944185..134967390)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene centromere protein E Neighboring gene predicted gene, 46826 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 Neighboring gene solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in siderophore biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in siderophore biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    3-hydroxybutyrate dehydrogenase type 2
    Names
    R-beta-hydroxybutyrate dehydrogenase
    dehydrogenase/reductase (SDR family) member 6
    NP_001165526.1
    NP_081484.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172055.1NP_001165526.1  3-hydroxybutyrate dehydrogenase type 2 isoform 1

      See identical proteins and their annotated locations for NP_001165526.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC104874
      Consensus CDS
      CCDS51073.1
      UniProtKB/TrEMBL
      G3UWD3
      Related
      ENSMUSP00000112683.3, ENSMUST00000120397.8
      Conserved Domains (2) summary
      cd05368
      Location:15255
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:12254
      PRK06138; short chain dehydrogenase; Provisional
    2. NM_027208.2NP_081484.1  3-hydroxybutyrate dehydrogenase type 2 isoform 2

      See identical proteins and their annotated locations for NP_081484.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC104874
      Consensus CDS
      CCDS17853.1
      UniProtKB/Swiss-Prot
      Q8JZV9
      Related
      ENSMUSP00000029817.8, ENSMUST00000029817.11
      Conserved Domains (2) summary
      cd05368
      Location:5245
      DHRS6_like_SDR_c; human DHRS6-like, classical (c) SDRs
      PRK06138
      Location:2244
      PRK06138; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      134986982..135010187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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