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    Calr3 calreticulin 3 [ Mus musculus (house mouse) ]

    Gene ID: 73316, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Calr3provided by MGI
    Official Full Name
    calreticulin 3provided by MGI
    Primary source
    MGI:MGI:1920566
    See related
    Ensembl:ENSMUSG00000019732 AllianceGenome:MGI:1920566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crt2; cspn; 1700031L01Rik; 6330586I20Rik
    Summary
    Enables protein folding chaperone. Predicted to be involved in protein folding and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in endoplasmic reticulum lumen and nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Is expressed in cerebral cortex and telencephalon. Orthologous to human CALR3 (calreticulin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 18.6) and heart adult (RPKM 2.7) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B3.3; 8 35.08 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (73178020..73197638, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72424176..72443819, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3785 Neighboring gene STARR-seq mESC enhancer starr_21854 Neighboring gene STARR-seq mESC enhancer starr_21858 Neighboring gene Kruppel-like transcription factor 2 (lung) Neighboring gene STARR-positive B cell enhancer ABC_E8247 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E9731 Neighboring gene STARR-positive B cell enhancer ABC_E5020 Neighboring gene predicted gene, 46043 Neighboring gene RIKEN cDNA 1700030K09 gene Neighboring gene STARR-positive B cell enhancer ABC_E359 Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene microRNA 7068

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Calsperin is a testis-specific chaperone required for sperm fertility. Ikawa M, et al. J Biol Chem, 2011 Feb 18. PMID 21131354, Free PMC Article
    2. Identification of a novel calreticulin isoform (Crt2) in human and mouse. Persson S, et al. Gene, 2002 Sep 4. PMID 12384296
    3. Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]. Tokuhiro K, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22357757, Free PMC Article
    4. GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice. Fujihara Y, et al. Biol Reprod, 2014 Mar. PMID 24501175
    5. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Easterday MC, et al. Dev Biol, 2003 Dec 15. PMID 14651920

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calsperin is a testis-specific chaperone required for sperm fertility.
      Title: Calsperin is a testis-specific chaperone required for sperm fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calreticulin-3
    Names
    calreticulin-2
    calspeculin
    calsperin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028500.3 → NP_082776.2  calreticulin-3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_082776.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK006582, AK046081
      Consensus CDS
      CCDS22413.1
      UniProtKB/Swiss-Prot
      G5E827, Q9D9Q6
      UniProtKB/TrEMBL
      B1Q2L7
      Related
      ENSMUSP00000019876.6, ENSMUST00000019876.12
      Conserved Domains (1) summary
      pfam00262
      Location:23 → 315
      Calreticulin; Calreticulin family

    2. NM_029782.3 → NP_084058.2  calreticulin-3 isoform 2

      See identical proteins and their annotated locations for NP_084058.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and 5' coding region, compared to variant 1. These differences result in a protein (isoform 2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK046081
      Consensus CDS
      CCDS40388.1
      UniProtKB/TrEMBL
      Q8BL82
      Related
      ENSMUSP00000105601.2, ENSMUST00000109974.2
      Conserved Domains (1) summary
      pfam00262
      Location:25 → 207
      Calreticulin; Calreticulin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      73178020..73197638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509761.5 → XP_006509824.1  calreticulin-3 isoform X1

      UniProtKB/TrEMBL
      B1Q2L7
      Conserved Domains (1) summary
      pfam00262
      Location:23 → 257
      Calreticulin; Calreticulin family

    2. XM_030243800.1 → XP_030099660.1  calreticulin-3 isoform X2

      Conserved Domains (1) summary
      pfam00262
      Location:25 → 149
      Calreticulin; Calreticulin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9Q6.2 GenPept UniProtKB/Swiss-Prot:Q9D9Q6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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