Use1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Use1provided by MGI
Official Full Name: unconventional SNARE in the ER 1 homolog (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:1914273
See related: Ensembl:ENSMUSG00000002395 AllianceGenome:MGI:1914273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D12; Ed2; p31; Q-snare; 2010315L10Rik; 5730403H22Rik
Summary: Predicted to enable SNAP receptor activity. Acts upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Predicted to be located in COPI-coated vesicle; Golgi apparatus; and plasma membrane. Predicted to be part of SNARE complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo mesoderm; optic vesicle; and primitive streak. Orthologous to human USE1 (unconventional SNARE in the ER 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 55.7), testis adult (RPKM 48.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.43 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71819329..71822376)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71366848..71369732)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Grsf1 controls translation of the protein Use1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site.
Title: Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.
Uba6 and Use1 promote proteasomal turnover of Ube3a in mouse embryo fibroblasts (MEFs) and catalyze Ube3a ubiquitylation in vitro.
Title: Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.
Domain analyses of Sec22b revealed that the R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis.
Title: Sec22b is a negative regulator of phagocytosis in macrophages.
p31 is an essential molecule involved in the maintenance of endoplasmic reticulum (ER) morphology and that its deficiency leads to ER stress-induced apoptosis.
Title: p31 deficiency influences endoplasmic reticulum tubular morphology and cell survival.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV002165 (e-PCR)
- UniSTS:164381

2010315L10Rik (e-PCR), detects polymorphism
- UniSTS:497311

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoplasmic reticulum tubular network organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of ER to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in COPI-coated vesicle	ISO Inferred from Sequence Orthology more info
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vesicle transport protein USE1

Names: USE1-like protein; embryonic development factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145780.1 → NP_001139252.1 vesicle transport protein USE1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate translational start codon, compared to variant 1. The encoded isoform (3) is longer at the N-terminus, compared to isoform 1.

Source sequence(s)

BC075695, BY097923

Consensus CDS

CCDS52582.1

UniProtKB/TrEMBL

E9Q496, Q5I940

Related

ENSMUSP00000105680.3, ENSMUST00000110053.9

Conserved Domains (1) summary

pfam09753
Location:31 → 280

Use1; Membrane fusion protein Use1
NM_025917.4 → NP_080193.1 vesicle transport protein USE1 isoform 1

See identical proteins and their annotated locations for NP_080193.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).

Source sequence(s)

AK160726, BC075695, BY286283

Consensus CDS

CCDS22390.1

UniProtKB/Swiss-Prot

Q3TUK0, Q80V73, Q99MB6, Q9CQ56

UniProtKB/TrEMBL

Q5I940

Related

ENSMUSP00000019169.8, ENSMUST00000019169.8

Conserved Domains (1) summary

pfam09753
Location:17 → 266

Use1; Membrane fusion protein Use1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

71819329..71822376

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154245.1 → XP_036010138.1 vesicle transport protein USE1 isoform X1

UniProtKB/TrEMBL

Q5I940

Conserved Domains (1) summary

pfam09753
Location:73 → 324

Use1; Membrane fusion protein Use1
XM_036154246.1 → XP_036010139.1 vesicle transport protein USE1 isoform X2

UniProtKB/TrEMBL

Q5I940

Conserved Domains (1) summary

pfam09753
Location:73 → 323

Use1; Membrane fusion protein Use1
XM_036154247.1 → XP_036010140.1 vesicle transport protein USE1 isoform X4

UniProtKB/TrEMBL

Q5I940

Conserved Domains (1) summary

pfam09753
Location:16 → 267

Use1; Membrane fusion protein Use1
XM_006509726.2 → XP_006509789.1 vesicle transport protein USE1 isoform X3

UniProtKB/TrEMBL

Q5I940

Conserved Domains (1) summary

pfam09753
Location:31 → 281

Use1; Membrane fusion protein Use1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_029768.3: Suppressed sequence

Description

NM_029768.3: This RefSeq was permanently suppressed because the CDS was partial and the transcript retained intronic sequence.