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    Trim35 tripartite motif-containing 35 [ Mus musculus (house mouse) ]

    Gene ID: 66854, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trim35provided by MGI
    Official Full Name
    tripartite motif-containing 35provided by MGI
    Primary source
    MGI:MGI:1914104
    See related
    Ensembl:ENSMUSG00000022043 AllianceGenome:MGI:1914104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NC8; HLS5; Mair; mKIAA1098; 0710005M05Rik; A430106H13Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; lung; and sensory organ. Orthologous to human TRIM35 (tripartite motif containing 35). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 102.9), adrenal adult (RPKM 97.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trim35 in Genome Data Viewer
    Location:
    14 D1; 14 34.44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66534474..66548873)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66297025..66311424)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene PTK2 protein tyrosine kinase 2 beta Neighboring gene STARR-positive B cell enhancer ABC_E7326 Neighboring gene STARR-seq mESC enhancer starr_36992 Neighboring gene predicted gene, 52098 Neighboring gene STARR-positive B cell enhancer ABC_E3121 Neighboring gene STARR-seq mESC enhancer starr_36993 Neighboring gene STARR-seq mESC enhancer starr_36994 Neighboring gene predicted gene, 52099 Neighboring gene STARR-positive B cell enhancer ABC_E7327 Neighboring gene STARR-seq mESC enhancer starr_36995 Neighboring gene RIKEN cDNA 1700001G11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:66915655-66915915 Neighboring gene STARR-positive B cell enhancer ABC_E8565 Neighboring gene predicted gene, 41183 Neighboring gene stathmin-like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tripartite motif-containing 35 (TRIM35) is up-regulated in UUO-induced renal fibrosis animal model. Chen Y, et al. Histol Histopathol, 2020 Dec. PMID 32955098
    2. Hls5 regulated erythroid differentiation by modulating GATA-1 activity. Endersby R, et al. Blood, 2008 Feb 15. PMID 18063753
    3. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2. Sun N, et al. Protein Cell, 2020 Dec. PMID 32562145, Free PMC Article
    4. Identification and validation of novel C/EBPbeta-regulated genes in preadipocyte proliferation. Liu M, et al. Chin Med J (Engl), 2010 May 5. PMID 20529561
    5. HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor. Lalonde JP, et al. J Biol Chem, 2004 Feb 27. PMID 14662771

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
      Title: The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
    2. Tripartite motif-containing 35 (TRIM35) is up-regulated in UUO-induced renal fibrosis animal model.
      Title: Tripartite motif-containing 35 (TRIM35) is up-regulated in UUO-induced renal fibrosis animal model.
    3. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
      Title: TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
    4. Data suggest that Trim35 (tripartite motif-containing 35) down-regulates type I interferon production in dendritic cells via toll-like receptors 7/9 and down-regulates stability of Irf7 (interferon regulatory factor 7) via ubiquitination/proteasomes.
      Title: TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7.
    5. C/EBPbeta may regulate preadipocyte proliferation through activation of banp and trim35.
      Title: Identification and validation of novel C/EBPbeta-regulated genes in preadipocyte proliferation.
    6. isolated from monocytoid variant, but not parental J2E erythroleukemia cells; expressed in wide range of adult tissues; at different stages of embryogenesis, Hls5 was detected in the branchial arches, spinal cord, dorsal root ganglia, limb buds, and brain
      Title: HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor.
    7. a novel RING-B-box-coiled-coil (RBCC) protein that consists of an N-terminal RING finger, followed by a B-box zinc finger, a coiled-coil domain, and a B30.2 domain; cloning and characterization
      Title: Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of myeloid cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of myeloid cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM35
    Names
    hemopoietic lineage switch protein 5
    macrophage-derived apoptosis-inducing RBCC protein
    protein Nc8
    tripartite motif-containing protein 35
    NP_084255.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029979.3 → NP_084255.2  E3 ubiquitin-protein ligase TRIM35

      See identical proteins and their annotated locations for NP_084255.2

      Status: VALIDATED

      Source sequence(s)
      AC140329, AF145374
      Consensus CDS
      CCDS27221.2
      UniProtKB/Swiss-Prot
      A6H681, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8C006, Q8VID4, Q9CW74, Q9D208
      UniProtKB/TrEMBL
      A0A0R4J031
      Related
      ENSMUSP00000022623.7, ENSMUST00000022623.13
      Conserved Domains (4) summary
      cd00021
      Location:114 → 152
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13863
      Location:166 → 262
      DUF4200; Domain of unknown function (DUF4200)
      cl02614
      Location:318 → 504
      SPRY; SPRY domain
      cl17238
      Location:33 → 77
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      66534474..66548873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C006.2 GenPept UniProtKB/Swiss-Prot:Q8C006

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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