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    Snx8 sorting nexin 8 [ Mus musculus (house mouse) ]

    Gene ID: 231834, updated on 23-Jun-2021

    Summary

    Official Symbol
    Snx8provided by MGI
    Official Full Name
    sorting nexin 8provided by MGI
    Primary source
    MGI:MGI:2443816
    See related
    Ensembl:ENSMUSG00000029560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B130023O14Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 15.1), spleen adult (RPKM 10.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Snx8 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140326048..140375063, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140340293..140389308, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (140816257..140865201, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene MAD1 mitotic arrest deficient 1-like 1 Neighboring gene predicted gene, 30492 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 1 Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene predicted gene, 30550 Neighboring gene microRNA 7038 Neighboring gene eukaryotic translation initiation factor 3, subunit B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in early endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172277.3NP_758481.1  sorting nexin-8

      See identical proteins and their annotated locations for NP_758481.1

      Status: VALIDATED

      Source sequence(s)
      AC131670, AK148429
      Consensus CDS
      CCDS39356.1
      UniProtKB/Swiss-Prot
      Q8CFD4
      Related
      ENSMUSP00000031539.8, ENSMUST00000031539.12
      Conserved Domains (2) summary
      cd06866
      Location:70173
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:190434
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      140326048..140375063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254436.2XP_030110296.1  sorting nexin-8 isoform X3

      Conserved Domains (2) summary
      cd06866
      Location:70173
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:176407
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
    2. XM_036165098.1XP_036020991.1  sorting nexin-8 isoform X6

      Conserved Domains (1) summary
      cd07597
      Location:1242
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
    3. XM_006504673.4XP_006504736.1  sorting nexin-8 isoform X2

      Conserved Domains (2) summary
      cd06866
      Location:71174
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:177408
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
    4. XM_006504672.2XP_006504735.1  sorting nexin-8 isoform X1

      Related
      ENSMUSP00000142556.2, ENSMUST00000196566.5
      Conserved Domains (2) summary
      cd06866
      Location:71174
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cd07597
      Location:191435
      BAR_SNX8; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 8
    5. XM_030254437.2XP_030110297.1  sorting nexin-8 isoform X5

      Conserved Domains (2) summary
      cd06866
      Location:70173
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cl12013
      Location:190300
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_006504674.5XP_006504737.1  sorting nexin-8 isoform X4

      Conserved Domains (2) summary
      cd06866
      Location:71174
      PX_SNX8_Mvp1p_like; The phosphoinositide binding Phox Homology domain of Sorting Nexin 8 and yeast Mvp1p
      cl12013
      Location:191301
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_001784687.3 RNA Sequence

      Related
      ENSMUST00000197880.5
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