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    Champ1 chromosome alignment maintaining phosphoprotein 1 [ Mus musculus (house mouse) ]

    Gene ID: 101994, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Champ1provided by MGI
    Official Full Name
    chromosome alignment maintaining phosphoprotein 1provided by MGI
    Primary source
    MGI:MGI:1196398
    See related
    Ensembl:ENSMUSG00000047710 AllianceGenome:MGI:1196398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp828; Znf828; mKIAA1802; D8Ertd457e; D8Ertd569e
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore and protein localization to organelle. Predicted to be located in Flemming body; kinetochore; and nuclear body. Predicted to be active in nucleoplasm and spindle. Is expressed in genitourinary system and liver. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 40. Orthologous to human CHAMP1 (chromosome alignment maintaining phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 12.3), CNS E14 (RPKM 11.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 A1.1; 8 6.4 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13919699..13931637)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13869641..13881639)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene SUMO/sentrin specific peptidase 2-like 2A Neighboring gene predicted gene, 53400 Neighboring gene predicted gene, 24698 Neighboring gene coordinator of PRMT5, differentiation stimulator Neighboring gene interferon induced transmembrane protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders. Zhou J, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35074918, Free PMC Article
    2. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article
    3. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
    4. Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells. Samudyata, et al. Exp Cell Res, 2019 Aug 1. PMID 31077711, Free PMC Article
    5. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sister chromatid biorientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sister chromatid biorientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chromosome alignment-maintaining phosphoprotein 1
    Names
    zinc finger protein 828

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363455.2 → NP_001350384.1  chromosome alignment-maintaining phosphoprotein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC139186
      Consensus CDS
      CCDS22116.1
      UniProtKB/Swiss-Prot
      Q3UZ85, Q6ZPI1, Q8K327
      Related
      ENSMUSP00000120117.3, ENSMUST00000128557.3
      Conserved Domains (2) summary
      sd00017
      Location:730 → 750
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl26464
      Location:109 → 466
      Atrophin-1; Atrophin-1 family

    2. NM_181854.3 → NP_862902.1  chromosome alignment-maintaining phosphoprotein 1

      See identical proteins and their annotated locations for NP_862902.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC139186
      Consensus CDS
      CCDS22116.1
      UniProtKB/Swiss-Prot
      Q3UZ85, Q6ZPI1, Q8K327
      Related
      ENSMUSP00000057270.8, ENSMUST00000051870.8
      Conserved Domains (2) summary
      sd00017
      Location:730 → 750
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl26464
      Location:109 → 466
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13919699..13931637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K327.1 GenPept UniProtKB/Swiss-Prot:Q8K327

    Gene LinkOut

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