U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cyb561a3 cytochrome b561 family, member A3 [ Mus musculus (house mouse) ]

    Gene ID: 225912, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cyb561a3provided by MGI
    Official Full Name
    cytochrome b561 family, member A3provided by MGI
    Primary source
    MGI:MGI:2686925
    See related
    Ensembl:ENSMUSG00000034445 AllianceGenome:MGI:2686925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lcytb; Cybasc3; 2310004G04Rik
    Summary
    Enables transmembrane ascorbate ferrireductase activity. Involved in cellular iron ion homeostasis. Located in late endosome membrane and lysosomal membrane. Is expressed in ganglia; jaw bone; and neural retina. Orthologous to human CYB561A3 (cytochrome b561 family member A3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 58.0), lung adult (RPKM 24.1) and 25 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cyb561a3 in Genome Data Viewer
    Location:
    19 A; 19 6.6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10554521..10574196)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10577157..10596832)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216 Neighboring gene STARR-positive B cell enhancer ABC_E9455 Neighboring gene transmembrane protein 138 Neighboring gene STARR-positive B cell enhancer ABC_E5687 Neighboring gene triokinase, FMN cyclase Neighboring gene damage specific DNA binding protein 1 Neighboring gene RIKEN cDNA 4930524O05 gene Neighboring gene von Willebrand factor C and EGF domains

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An ascorbate-reducible cytochrome b561 is localized in macrophage lysosomes. Zhang DL, et al. Biochim Biophys Acta, 2006 Dec. PMID 16996694
    2. Three mammalian cytochromes b561 are ascorbate-dependent ferrireductases. Su D, et al. FEBS J, 2006 Aug. PMID 16911521
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC86114, 2310004G04Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane ascorbate ferrireductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    lysosomal membrane ascorbate-dependent ferrireductase CYB561A3
    Names
    cytochrome b ascorbate-dependent protein 3
    lysosomal cytochrome b
    NP_001268993.1
    NP_001268994.1
    NP_001268996.1
    NP_001349359.1
    NP_001349360.1
    NP_958739.1
    XP_006527001.1
    XP_006527002.1
    XP_006527003.1
    XP_017173636.1
    XP_030106739.1
    XP_030106742.1
    XP_030106743.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282064.1 → NP_001268993.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

      See identical proteins and their annotated locations for NP_001268993.1

      Status: VALIDATED

      Source sequence(s)
      AC125093, AK139533, AK168841, BY387699
      Consensus CDS
      CCDS29582.1
      UniProtKB/Swiss-Prot
      Q3TVE2, Q3V3G2, Q6P1H1
      Related
      ENSMUSP00000157672.2, ENSMUST00000235271.2
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    2. NM_001282065.1 → NP_001268994.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 2

      See identical proteins and their annotated locations for NP_001268994.1

      Status: VALIDATED

      Source sequence(s)
      AC125093, AK139533, AK160179, AK168841, BY387699
      Consensus CDS
      CCDS89344.1
      UniProtKB/Swiss-Prot
      Q6P1H1
      Related
      ENSMUSP00000157602.2, ENSMUST00000237641.2
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    3. NM_001282067.2 → NP_001268996.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

      See identical proteins and their annotated locations for NP_001268996.1

      Status: VALIDATED

      Source sequence(s)
      AK139533, AK168841, BY387699
      Consensus CDS
      CCDS29582.1
      UniProtKB/Swiss-Prot
      Q3TVE2, Q3V3G2, Q6P1H1
      Related
      ENSMUSP00000157884.2, ENSMUST00000237581.2
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    4. NM_001362430.1 → NP_001349359.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125093
      Consensus CDS
      CCDS29582.1
      UniProtKB/Swiss-Prot
      Q3TVE2, Q3V3G2, Q6P1H1
      Related
      ENSMUSP00000130680.2, ENSMUST00000168445.2
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    5. NM_001362431.1 → NP_001349360.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125093
      Consensus CDS
      CCDS29582.1
      UniProtKB/Swiss-Prot
      Q3TVE2, Q3V3G2, Q6P1H1
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    6. NM_201351.2 → NP_958739.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform 1

      See identical proteins and their annotated locations for NP_958739.1

      Status: VALIDATED

      Source sequence(s)
      AC125093, AK139533, AK168841, BY387699
      Consensus CDS
      CCDS29582.1
      UniProtKB/Swiss-Prot
      Q3TVE2, Q3V3G2, Q6P1H1
      Related
      ENSMUSP00000158186.2, ENSMUST00000237814.2
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10554521..10574196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526940.4 → XP_006527003.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X2

      See identical proteins and their annotated locations for XP_006527003.1

      UniProtKB/Swiss-Prot
      Q6P1H1
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    2. XM_030250883.2 → XP_030106743.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

      UniProtKB/Swiss-Prot
      Q3TVE2, Q3V3G2, Q6P1H1
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    3. XM_017318147.3 → XP_017173636.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

      Related
      ENSMUSP00000157892.2, ENSMUST00000236352.2
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    4. XM_006526938.5 → XP_006527001.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

      See identical proteins and their annotated locations for XP_006527001.1

      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    5. XM_030250879.1 → XP_030106739.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    6. XM_006526939.5 → XP_006527002.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

      See identical proteins and their annotated locations for XP_006527002.1

      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    7. XM_030250882.2 → XP_030106742.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

      UniProtKB/Swiss-Prot
      Q3TVE2, Q3V3G2, Q6P1H1
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1H1.1 GenPept UniProtKB/Swiss-Prot:Q6P1H1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous