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    Hsdl1 hydroxysteroid dehydrogenase like 1 [ Mus musculus (house mouse) ]

    Gene ID: 72552, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hsdl1provided by MGI
    Official Full Name
    hydroxysteroid dehydrogenase like 1provided by MGI
    Primary source
    MGI:MGI:1919802
    See related
    Ensembl:ENSMUSG00000034189 AllianceGenome:MGI:1919802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700067E09Rik
    Summary
    Located in mitochondrion. Is expressed in central nervous system; retina inner nuclear layer; retina layer; and retina outer nuclear layer. Orthologous to human HSDL1 (hydroxysteroid dehydrogenase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 41.1), whole brain E14.5 (RPKM 20.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E1; 8 67.95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120288717..120301930, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119561978..119575214, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 38, member 8 Neighboring gene STARR-seq mESC enhancer starr_22850 Neighboring gene membrane-bound transcription factor peptidase, site 1 Neighboring gene STARR-seq mESC enhancer starr_22853 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122082621-122082922 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122087691-122087878 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122087910-122088232 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122093859-122094132 Neighboring gene STARR-seq mESC enhancer starr_22854 Neighboring gene dynein, axonemal assembly factor 1 Neighboring gene STARR-seq mESC enhancer starr_22855 Neighboring gene ribosomal protein S13, pseudogene 4 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    2. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
    3. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive hydroxysteroid dehydrogenase-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379016.1 → NP_001365945.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
      Source sequence(s)
      AC104882
      UniProtKB/Swiss-Prot
      Q3U839, Q8BTX9
      Conserved Domains (1) summary
      cd05356
      Location:67 → 309
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    2. NM_001379017.1 → NP_001365946.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC104882
      UniProtKB/Swiss-Prot
      Q3U839, Q8BTX9
      Conserved Domains (1) summary
      cd05356
      Location:67 → 309
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    3. NM_001379018.1 → NP_001365947.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC104882
      UniProtKB/TrEMBL
      A0A1D5RLG0
      Conserved Domains (1) summary
      cd05356
      Location:46 → 288
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    4. NM_175185.5 → NP_780394.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform a

      See identical proteins and their annotated locations for NP_780394.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
      Source sequence(s)
      AC104882
      Consensus CDS
      CCDS22708.1
      UniProtKB/Swiss-Prot
      Q3U839, Q8BTX9
      Related
      ENSMUSP00000044371.5, ENSMUST00000036049.6
      Conserved Domains (1) summary
      cd05356
      Location:67 → 309
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    RNA

    1. NR_166413.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104882

    2. NR_166414.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104882

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120288717..120301930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531397.5 → XP_006531460.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006531460.1

      UniProtKB/Swiss-Prot
      Q3U839, Q8BTX9
      Conserved Domains (1) summary
      cd05356
      Location:67 → 309
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    2. XM_036154310.1 → XP_036010203.1  inactive hydroxysteroid dehydrogenase-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLG0
      Related
      ENSMUSP00000148352.2, ENSMUST00000212517.2
      Conserved Domains (1) summary
      cd05356
      Location:46 → 288
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    RNA

    1. XR_003947344.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTX9.1 GenPept UniProtKB/Swiss-Prot:Q8BTX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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