Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Kyat3 kynurenine aminotransferase 3 [ Mus musculus (house mouse) ]

    Gene ID: 229905, updated on 6-May-2021

    Summary

    Official Symbol
    Kyat3provided by MGI
    Official Full Name
    kynurenine aminotransferase 3provided by MGI
    Primary source
    MGI:MGI:2677849
    See related
    Ensembl:ENSMUSG00000040213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KA; Kat; Ccbl; Kat3; Ccbl2; KATIII
    Expression
    Broad expression in liver E18 (RPKM 19.4), liver adult (RPKM 18.7) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kyat3 in Genome Data Viewer
    Location:
    3; 3 H1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142406780..142450672)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142701019..142744911)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (142364044..142407874)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 2, pseudogene Neighboring gene human immunodeficiency virus type I enhancer binding protein 1 pseudogene Neighboring gene general transcription factor IIB Neighboring gene predicted gene, 24457 Neighboring gene predicted gene, 25965 Neighboring gene protein kinase N2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • C430041M20

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-S-conjugate beta-lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kynurenine aminotransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kynurenine-glyoxylate transaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kynurenine-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables kynurenine-oxoglutarate transaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular amino acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in kynurenine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    kynurenine--oxoglutarate transaminase 3
    Names
    cysteine conjugate-beta lyase 2
    cysteine-S-conjugate beta-lyase 2
    kynurenine aminotransferase III
    kynurenine--glyoxylate transaminase
    kynurenine--oxoglutarate transaminase III
    NP_001280489.1
    NP_776124.1
    XP_006501494.1
    XP_011238416.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293560.1NP_001280489.1  kynurenine--oxoglutarate transaminase 3 isoform1

      See identical proteins and their annotated locations for NP_001280489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC115865, AK049569, AK145623
      Consensus CDS
      CCDS80040.1
      UniProtKB/Swiss-Prot
      Q71RI9
      Related
      ENSMUSP00000101825.2, ENSMUST00000106218.8
      Conserved Domains (2) summary
      cd00609
      Location:67449
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK07777
      Location:45450
      PRK07777; aminotransferase; Validated
    2. NM_173763.4NP_776124.1  kynurenine--oxoglutarate transaminase 3 isoform 2

      See identical proteins and their annotated locations for NP_776124.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in a 5' exon resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC115865, AK049569, AK145623
      Consensus CDS
      CCDS17881.1
      UniProtKB/Swiss-Prot
      Q71RI9
      Related
      ENSMUSP00000041675.5, ENSMUST00000044392.11
      Conserved Domains (1) summary
      PRK07777
      Location:10415
      PRK07777; putative succinyldiaminopimelate transaminase DapC

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      142406780..142450672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501431.3XP_006501494.1  kynurenine--oxoglutarate transaminase 3 isoform X1

      See identical proteins and their annotated locations for XP_006501494.1

      UniProtKB/Swiss-Prot
      Q71RI9
      Conserved Domains (1) summary
      PRK07777
      Location:10415
      PRK07777; putative succinyldiaminopimelate transaminase DapC
    2. XM_011240114.4XP_011238416.1  kynurenine--oxoglutarate transaminase 3 isoform X1

      See identical proteins and their annotated locations for XP_011238416.1

      UniProtKB/Swiss-Prot
      Q71RI9
      Conserved Domains (1) summary
      PRK07777
      Location:10415
      PRK07777; putative succinyldiaminopimelate transaminase DapC
    Support Center