Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grin2bprovided by MGI
Official Full Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)provided by MGI
Primary source: MGI:MGI:95821
See related: Ensembl:ENSMUSG00000030209 AllianceGenome:MGI:95821
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NR2B; GluN2B; Nmdar2b; GluRepsilon2
Summary: Enables NMDA glutamate receptor activity; calcium channel activity; and neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Involved in negative regulation of dendritic spine maintenance and positive regulation of neuron death. Acts upstream of or within several processes, including behavioral fear response; detection of mechanical stimulus involved in sensory perception of pain; and learning or memory. Located in several cellular components, including cytoplasmic vesicle; lysosome; and synaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including adipose tissue; central nervous system; eye; gut; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant non-syndromic intellectual disability 6; bipolar disorder; developmental and epileptic encephalopathy 27; and neurodegenerative disease (multiple). Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 5.7), frontal lobe adult (RPKM 5.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 66.38 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (135690219..136150658, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (135713221..136173615, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of GluN2B-containing NMDA receptors in early life combined with social stress in adulthood leads to alterations in prefrontal PNNs in mice.
Title: Inhibition of GluN2B-containing NMDA receptors in early life combined with social stress in adulthood leads to alterations in prefrontal PNNs in mice.
A novel dopamine D2 receptor-NR2B protein complex might contribute to morphine use disorders.
Title: A novel dopamine D2 receptor-NR2B protein complex might contribute to morphine use disorders.
N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease.
Title: N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease.
GluN2B inhibition confers resilience against long-term cocaine-induced neurocognitive sequelae.
Title: GluN2B inhibition confers resilience against long-term cocaine-induced neurocognitive sequelae.
A decrease in NR2B expression mediated by DNA hypermethylation induces perioperative neurocognitive disorder in aged mice.
Title: A decrease in NR2B expression mediated by DNA hypermethylation induces perioperative neurocognitive disorder in aged mice.
NMDA Receptor C-Terminal Domain Signalling in Development, Maturity, and Disease.
Title: NMDA Receptor C-Terminal Domain Signalling in Development, Maturity, and Disease.
Differential roles of NMDAR subunits 2A and 2B in mediating peripheral and central sensitization contributing to orofacial neuropathic pain.
Title: Differential roles of NMDAR subunits 2A and 2B in mediating peripheral and central sensitization contributing to orofacial neuropathic pain.
Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1).
Title: Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1).
Down-regulation of NR2B receptors contributes to the analgesic and antianxiety effects of enriched environment mediated by endocannabinoid system in the inflammatory pain mice.
Title: Down-regulation of NR2B receptors contributes to the analgesic and antianxiety effects of enriched environment mediated by endocannabinoid system in the inflammatory pain mice.
KIF17 Modulates Epileptic Seizures and Membrane Expression of the NMDA Receptor Subunit NR2B.
Title: KIF17 Modulates Epileptic Seizures and Membrane Expression of the NMDA Receptor Subunit NR2B.

Submit: New GeneRIF Correction See all GeneRIFs (223)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (18) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW490526 (e-PCR)
- UniSTS:179480

D6Mit301 (e-PCR), detects polymorphism
- UniSTS:130852

ha3042 (e-PCR)
- UniSTS:515631

Grin2b (e-PCR), detects polymorphism
- UniSTS:143262

RH94750 (e-PCR)
- UniSTS:119997

UniSTS:465389 (e-PCR)
- UniSTS:465389

Grin2b (e-PCR), detects polymorphism
- UniSTS:465389

Grin2b (e-PCR), detects polymorphism
- UniSTS:531449

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D2 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables NMDA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables NMDA glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables NMDA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables extracellularly glutamate-gated ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate binding	ISO Inferred from Sequence Orthology more info
enables glutamate-gated calcium ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables glycine binding	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1 receptor binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NMDA selective glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in action potential	ISO Inferred from Sequence Orthology more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral fear response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fear response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	TAS Traceable Author Statement more info	PubMed
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-term synaptic potentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic cation transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendritic spine maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of ARF protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of neuronal synaptic plasticity	TAS Traceable Author Statement more info	PubMed
involved_in regulation of postsynaptic cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein kinase A signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to organonitrogen compound	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	ISO Inferred from Sequence Orthology more info
involved_in sensitization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within startle response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within suckling behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NMDA selective glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in apical dendrite	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendritic branch	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic cleft	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info
located_in transport vesicle membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 2B

Names: N-methyl D-aspartate receptor subtype 2B; glutamate [NMDA] receptor subunit epsilon-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363750.1 → NP_001350679.1 glutamate receptor ionotropic, NMDA 2B precursor

Status: VALIDATED

Source sequence(s)

AC124500, AC124590, AC132119, AC161364

Consensus CDS

CCDS20648.1

UniProtKB/Swiss-Prot

Q01097, Q9DCB2

UniProtKB/TrEMBL

G3X9V4

Conserved Domains (3) summary

cd13718
Location:403 → 803

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:33 → 388

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:840 → 1482

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
NM_008171.4 → NP_032197.3 glutamate receptor ionotropic, NMDA 2B precursor

See identical proteins and their annotated locations for NP_032197.3

Status: VALIDATED

Source sequence(s)

AC124500, AC124590, AC132119, AC161364

Consensus CDS

CCDS20648.1

UniProtKB/Swiss-Prot

Q01097, Q9DCB2

UniProtKB/TrEMBL

G3X9V4

Related

ENSMUSP00000107536.2, ENSMUST00000111905.8

Conserved Domains (3) summary

cd13718
Location:403 → 803

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:33 → 388

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:840 → 1482

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

135690219..136150658 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241221.4 → XP_011239523.1 glutamate receptor ionotropic, NMDA 2B isoform X1

See identical proteins and their annotated locations for XP_011239523.1

UniProtKB/Swiss-Prot

Q01097, Q9DCB2

UniProtKB/TrEMBL

G3X9V4

Conserved Domains (3) summary

cd13718
Location:403 → 803

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:33 → 388

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:840 → 1482

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_006505575.5 → XP_006505638.1 glutamate receptor ionotropic, NMDA 2B isoform X1

See identical proteins and their annotated locations for XP_006505638.1

UniProtKB/Swiss-Prot

Q01097, Q9DCB2

UniProtKB/TrEMBL

G3X9V4

Conserved Domains (3) summary

cd13718
Location:403 → 803

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:33 → 388

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:840 → 1482

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_006505574.5 → XP_006505637.1 glutamate receptor ionotropic, NMDA 2B isoform X1

See identical proteins and their annotated locations for XP_006505637.1

UniProtKB/Swiss-Prot

Q01097, Q9DCB2

UniProtKB/TrEMBL

G3X9V4

Conserved Domains (3) summary

cd13718
Location:403 → 803

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:33 → 388

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:840 → 1482

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_006505573.5 → XP_006505636.1 glutamate receptor ionotropic, NMDA 2B isoform X1

See identical proteins and their annotated locations for XP_006505636.1

UniProtKB/Swiss-Prot

Q01097, Q9DCB2

UniProtKB/TrEMBL

G3X9V4

Conserved Domains (3) summary

cd13718
Location:403 → 803

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:33 → 388

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:840 → 1482

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
XM_036165858.1 → XP_036021751.1 glutamate receptor ionotropic, NMDA 2B isoform X1

UniProtKB/Swiss-Prot

Q01097, Q9DCB2

UniProtKB/TrEMBL

G3X9V4

Conserved Domains (3) summary

cd13718
Location:403 → 803

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:33 → 388

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:840 → 1482

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus