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    Camkmt calmodulin-lysine N-methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 73582, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Camkmtprovided by MGI
    Official Full Name
    calmodulin-lysine N-methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1920832
    See related
    Ensembl:ENSMUSG00000071037 AllianceGenome:MGI:1920832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLNMT; CaM KMT; 1700106N22Rik
    Summary
    Enables calmodulin-lysine N-methyltransferase activity. Acts upstream of or within mitochondrion organization and peptidyl-lysine methylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in maxillary process. Used to study hypotonia-cystinuria syndrome. Orthologous to human CAMKMT (calmodulin-lysine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 1.2), testis adult (RPKM 0.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E4; 17 55.2 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (85397989..85766017)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (85090561..85458589)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110020A21 gene Neighboring gene STARR-positive B cell enhancer mm9_chr17:85356735-85357036 Neighboring gene STARR-seq mESC enhancer starr_43457 Neighboring gene protein phosphatase 1B, magnesium dependent, beta isoform Neighboring gene STARR-positive B cell enhancer ABC_E9445 Neighboring gene solute carrier family 3, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4233 Neighboring gene STARR-seq mESC enhancer starr_43458 Neighboring gene prolyl endopeptidase-like Neighboring gene STARR-seq mESC enhancer starr_43460 Neighboring gene STARR-seq mESC enhancer starr_43463 Neighboring gene STARR-positive B cell enhancer mm9_chr17:85588997-85589298 Neighboring gene STARR-seq mESC enhancer starr_43464 Neighboring gene predicted gene, 36826 Neighboring gene STARR-seq mESC enhancer starr_43465 Neighboring gene STARR-seq mESC enhancer starr_43466 Neighboring gene STARR-seq mESC enhancer starr_43468 Neighboring gene STARR-seq mESC enhancer starr_43469 Neighboring gene STARR-seq mESC enhancer starr_43471 Neighboring gene ribosomal protein L31, pseudogene 16 Neighboring gene STARR-seq mESC enhancer starr_43472 Neighboring gene developmentally regulated GTP binding protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Calmodulin Methyltransferase Is Required for Growth, Muscle Strength, Somatosensory Development and Brain Function. Haziza S, et al. PLoS Genet, 2015 Aug. PMID 26247364, Free PMC Article
    2. Developmental constraint through negative pleiotropy in the zygomatic arch. Percival CJ, et al. Evodevo, 2018. PMID 29423138, Free PMC Article
    3. Identification of novel markers of mouse fetal ovary development. Chen H, et al. PLoS One, 2012. PMID 22844512, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CaM methylation appears to have a role in growth, muscle strength, somatosensory development and brain function.
      Title: Calmodulin Methyltransferase Is Required for Growth, Muscle Strength, Somatosensory Development and Brain Function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin-lysine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-lysine N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidyl-lysine methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin-lysine N-methyltransferase
    NP_001351875.1
    NP_082852.1
    XP_006525055.1
    XP_006525056.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364946.1 → NP_001351875.1  calmodulin-lysine N-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113476, BB621809, BQ175501, CN533503

    2. NM_028576.3 → NP_082852.1  calmodulin-lysine N-methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_082852.1

      Status: VALIDATED

      Source sequence(s)
      AC113476, AC154217, AC154475
      Consensus CDS
      CCDS37712.1
      UniProtKB/Swiss-Prot
      Q3U2J5, Q9D9C5
      UniProtKB/TrEMBL
      B9EHP1
      Related
      ENSMUSP00000092811.6, ENSMUST00000095188.7
      Conserved Domains (1) summary
      cl17173
      Location:113 → 278
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      85397989..85766017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524992.3 → XP_006525055.1  calmodulin-lysine N-methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006525055.1

      Conserved Domains (1) summary
      cl17173
      Location:113 → 253
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_006524993.5 → XP_006525056.1  calmodulin-lysine N-methyltransferase isoform X2

    RNA

    1. XR_385373.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U2J5.1 GenPept UniProtKB/Swiss-Prot:Q3U2J5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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