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    Alg6 ALG6 alpha-1,3-glucosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 320438, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Alg6provided by MGI
    Official Full Name
    ALG6 alpha-1,3-glucosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2444031
    See related
    Ensembl:ENSMUSG00000073792 AllianceGenome:MGI:2444031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E230028F23Rik
    Summary
    Predicted to enable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity. Predicted to be involved in oligosaccharide-lipid intermediate biosynthetic process and protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in metanephros. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ic. Orthologous to human ALG6 (ALG6 alpha-1,3-glucosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 4.7), placenta adult (RPKM 4.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Alg6 in Genome Data Viewer
    Location:
    4 C6; 4 45.71 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (99603833..99651697)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (99715596..99763460)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene non-SMC element 1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_10869 Neighboring gene STARR-seq mESC enhancer starr_10871 Neighboring gene STARR-seq mESC enhancer starr_10873 Neighboring gene forkhead box D3 Neighboring gene STARR-positive B cell enhancer ABC_E6192 Neighboring gene STARR-seq mESC enhancer starr_10875 Neighboring gene integrin beta 3 binding protein (beta3-endonexin) Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:99495752-99496005 Neighboring gene EF-hand calcium binding domain 7 Neighboring gene predicted gene, 26425

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. Pandey P, et al. BMC Syst Biol, 2011 Apr 25. PMID 21518438, Free PMC Article
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oligosaccharide-lipid intermediate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
    Names
    asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
    asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase)
    asparagine-linked glycosylation protein 6 homolog
    dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase
    dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
    NP_001074733.1
    XP_006503218.1
    XP_006503219.1
    XP_006503221.1
    XP_006503223.1
    XP_006503224.1
    XP_006503225.1
    XP_006503226.1
    XP_006503227.1
    XP_017175746.1
    XP_030109465.1
    XP_036020078.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081264.1 → NP_001074733.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor

      See identical proteins and their annotated locations for NP_001074733.1

      Status: VALIDATED

      Source sequence(s)
      BX005053
      Consensus CDS
      CCDS38818.1
      UniProtKB/Swiss-Prot
      Q3TAE8, Q3TZF4
      Related
      ENSMUSP00000095574.3, ENSMUST00000097961.9
      Conserved Domains (1) summary
      pfam03155
      Location:32 → 487
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      99603833..99651697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503158.2 → XP_006503221.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X3

      Conserved Domains (1) summary
      pfam03155
      Location:32 → 333
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    2. XM_006503161.2 → XP_006503224.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X5

      Conserved Domains (1) summary
      cl21590
      Location:32 → 346
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    3. XM_036164185.1 → XP_036020078.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X6

      Conserved Domains (1) summary
      pfam03155
      Location:32 → 351
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    4. XM_017320257.1 → XP_017175746.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X8

      Conserved Domains (1) summary
      cl21590
      Location:12 → 268
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    5. XM_030253605.1 → XP_030109465.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X4

      Conserved Domains (1) summary
      pfam03155
      Location:7 → 357
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    6. XM_006503155.1 → XP_006503218.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X1

      Conserved Domains (1) summary
      pfam03155
      Location:32 → 457
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    7. XM_006503156.1 → XP_006503219.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X2

      Conserved Domains (1) summary
      pfam03155
      Location:13 → 390
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    8. XM_006503162.1 → XP_006503225.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X7

      Conserved Domains (1) summary
      cl21590
      Location:60 → 316
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    9. XM_006503164.1 → XP_006503227.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X9

      Conserved Domains (1) summary
      cl21590
      Location:47 → 242
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    10. XM_006503160.1 → XP_006503223.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X4

      See identical proteins and their annotated locations for XP_006503223.1

      Conserved Domains (1) summary
      pfam03155
      Location:7 → 357
      Alg6_Alg8; ALG6, ALG8 glycosyltransferase family

    11. XM_006503163.5 → XP_006503226.1  dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase isoform X8

      Conserved Domains (1) summary
      cl21590
      Location:12 → 268
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TAE8.1 GenPept UniProtKB/Swiss-Prot:Q3TAE8

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