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    Zfp68 zinc finger protein 68 [ Mus musculus (house mouse) ]

    Gene ID: 24135, updated on 27-Feb-2024

    Summary

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    Official Symbol
    Zfp68provided by MGI
    Official Full Name
    zinc finger protein 68provided by MGI
    Primary source
    MGI:MGI:1344427
    See related
    Ensembl:ENSMUSG00000058291 AllianceGenome:MGI:1344427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KRAB3; KRAZ2; Zfp70; mszf22; mszf49
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; female associated reproductive structure; inner cell mass; oocyte; and ovary. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E14 (RPKM 10.5), CNS E18 (RPKM 9.5) and 24 other tissues See more
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    Genomic context

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    Location:
    5 G2; 5 77.1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138601914..138618005, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138603652..138619743, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor, pseudogene 24 Neighboring gene RIKEN cDNA 1700123K08 gene Neighboring gene STARR-seq mESC enhancer starr_14669 Neighboring gene RIKEN cDNA A430033K04 gene Neighboring gene STARR-positive B cell enhancer ABC_E1314 Neighboring gene STARR-seq mESC enhancer starr_14671 Neighboring gene STARR-seq mESC enhancer starr_14672 Neighboring gene STARR-seq mESC enhancer starr_14673 Neighboring gene FAM20C, golgi associated secretory pathway kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two novel Krüppel-associated box-containing zinc-finger proteins, KRAZ1 and KRAZ2, repress transcription through functional interaction with the corepressor KAP-1 (TIF1beta/KRIP-1). Agata Y, et al. J Biol Chem, 1999 Jun 4. PMID 10347202
    2. An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse. Percec I, et al. Genetics, 2003 Aug. PMID 12930754, Free PMC Article
    3. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    4. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    5. Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice. O'Leary J, et al. PLoS One, 2011. PMID 21909369, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 68
    Names
    zinc finger protein 70

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044747.2 → NP_001038212.1  zinc finger protein 68 isoform b

      See identical proteins and their annotated locations for NP_001038212.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' end which causes translation initiation from a downstream, in-frame start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK044831, AK082025, BY088951
      Consensus CDS
      CCDS39347.1
      UniProtKB/TrEMBL
      Q8BLK6
      Related
      ENSMUSP00000083013.5, ENSMUST00000085852.11
      Conserved Domains (4) summary
      smart00349
      Location:1 → 32
      KRAB; krueppel associated box
      COG5048
      Location:475 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:337 → 357
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:378 → 402
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001163797.1 → NP_001157269.1  zinc finger protein 68 isoform a

      See identical proteins and their annotated locations for NP_001157269.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AK044831, AK082025, AK146092, BY088951
      Consensus CDS
      CCDS19801.1
      UniProtKB/TrEMBL
      Q9Z116
      Related
      ENSMUSP00000069615.5, ENSMUST00000063262.11
      Conserved Domains (6) summary
      smart00349
      Location:10 → 70
      KRAB; krueppel associated box
      COG5048
      Location:234 → 475
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:375 → 395
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:541 → 563
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:10 → 49
      KRAB; KRAB box
      pfam13465
      Location:416 → 440
      zf-H2C2_2; Zinc-finger double domain

    3. NM_013844.2 → NP_038872.1  zinc finger protein 68 isoform a

      See identical proteins and their annotated locations for NP_038872.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AB024005, AK082025, BY088951
      Consensus CDS
      CCDS19801.1
      UniProtKB/TrEMBL
      Q9Z116
      Related
      ENSMUSP00000106530.3, ENSMUST00000110905.9
      Conserved Domains (6) summary
      smart00349
      Location:10 → 70
      KRAB; krueppel associated box
      COG5048
      Location:234 → 475
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:375 → 395
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:541 → 563
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:10 → 49
      KRAB; KRAB box
      pfam13465
      Location:416 → 440
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138601914..138618005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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