Onecut2 one cut domain, family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Onecut2provided by MGI
Official Full Name: one cut domain, family member 2provided by MGI
Primary source: MGI:MGI:1891408
See related: Ensembl:ENSMUSG00000045991 AllianceGenome:MGI:1891408
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Oc2; OC-2; C730009D12
Summary: Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including liver development; negative regulation of transforming growth factor beta receptor signaling pathway; and peripheral nervous system neuron development. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future brain; genitourinary system; gut; and retina. Orthologous to human ONECUT2 (one cut homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 3.0), duodenum adult (RPKM 1.9) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 37.33 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (64473098..64531559)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (64340032..64398488)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ASH2L regulates postnatal neurogenesis through Onecut2-mediated inhibition of TGF-beta signaling pathway.
Title: ASH2L regulates postnatal neurogenesis through Onecut2-mediated inhibition of TGF-β signaling pathway.
ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study.
Title: ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study.
ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY.
Title: ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY.
Onecut1 and Onecut2 have roles in operating downstream of Pax6 to regulate horizontal cell development
Title: Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development.
similar to Onecut1, Onecut2 is also necessary for the formation of normal numbers of horizontal cells in the developing retina.
Title: Onecut1 and Onecut2 play critical roles in the development of the mouse retina.
identified downstream genes of Oc1 and Oc2 that shows that the onecut factors suppress the production of the late cell type, rods, indicating that the two factors contribute to the competence of retinal progenitor cells for early retinal cell fates
Title: Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development.
OC-2 is required for development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus.
Title: Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus.
Onecut2 and Onecut1 have similar expression patterns throughout retinal development and may also function in the genesis and maintenance of retinal horizontal cells.
Title: Onecut 1 and Onecut 2 are potential regulators of mouse retinal development.
Data show that Onecut-2/Onecut-3 double knockout is a perinatal lethal.
Title: Onecut-2 knockout mice fail to thrive during early postnatal period and have altered patterns of gene expression in small intestine.
These results indicate that the expression of HNF-6 and OC-2 regulators of liver and pancreas development is modulated by miR-495 and miR-218.
Title: MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Onecut2 (e-PCR), detects polymorphism
- UniSTS:265532

NoName (e-PCR)
- UniSTS:489565

Onecut2 (e-PCR), detects polymorphism
- UniSTS:525504

RH131469 (e-PCR)
- UniSTS:214752

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anatomical structure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocrine pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of mesenchymal stem cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within peripheral nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mesenchymal stem cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell-matrix adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: one cut domain family member 2

Names: one cut homeobox 2; transcription factor ONECUT-2; transcription factor ONECUT2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194268.3 → NP_919244.2 one cut domain family member 2

See identical proteins and their annotated locations for NP_919244.2

Status: VALIDATED

Source sequence(s)

AC102106

Consensus CDS

CCDS29302.2

UniProtKB/Swiss-Prot

Q6XBJ3

UniProtKB/TrEMBL

Q3ZAT5

Related

ENSMUSP00000135692.3, ENSMUST00000175965.10

Conserved Domains (2) summary

smart00389
Location:427 → 482

HOX; Homeodomain

pfam02376
Location:332 → 404

CUT; CUT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

64473098..64531559

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250441.1 → XP_030106301.1 one cut domain family member 2 isoform X1

Conserved Domains (1) summary

pfam02376
Location:332 → 400

CUT; CUT domain