Tars1 threonyl-tRNA synthetase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tars1provided by MGI
Official Full Name: threonyl-tRNA synthetase 1provided by MGI
Primary source: MGI:MGI:106314
See related: Ensembl:ENSMUSG00000022241 AllianceGenome:MGI:106314
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tars; ThrRS; D15Wsu59e
Summary: Enables threonine-tRNA ligase activity. Involved in threonyl-tRNA aminoacylation. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; liver; and sensory organ. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 7. Orthologous to human TARS1 (threonyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 35.0), liver E14 (RPKM 27.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 5.6 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (11383749..11399744, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (11383663..11399658, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A non-translational role of threonyl-tRNA synthetase in regulating JNK signaling during myogenic differentiation.
Title: A non-translational role of threonyl-tRNA synthetase in regulating JNK signaling during myogenic differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124912 (e-PCR)
- UniSTS:161734

RH125909 (e-PCR)
- UniSTS:142030

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables threonine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables threonine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables threonine-tRNA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables threonine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in threonyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in threonyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
involved_in threonyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: threonine--tRNA ligase 1, cytoplasmic

Names: threonine--tRNA ligase, cytoplasmic; threonyl-tRNA synthetase, cytoplasmic

NP_149065.2

EC 6.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.