TOB1 transducer of ERBB2, 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TOB1provided by HGNC
Official Full Name: transducer of ERBB2, 1provided by HGNC
Primary source: HGNC:HGNC:11979
See related: Ensembl:ENSG00000141232 MIM:605523; AllianceGenome:HGNC:11979
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TOB; TROB; APRO5; APRO6; PIG49; TROB1
Summary: This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression: Ubiquitous expression in adrenal (RPKM 113.0), thyroid (RPKM 46.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.33

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (50862223..50867978, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (51729361..51735122, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (48939584..48945339, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma.
Title: Methylation Mediated Downregulation of TOB1-AS1 and TOB1 Correlates with Malignant Progression and Poor Prognosis of Esophageal Squamous Cell Carcinoma.
Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway.
Title: Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway.
Identification of miR253p as a tumor biomarker: Regulation of cellular functions via TOB1 in breast cancer.
Title: Identification of miR‑25‑3p as a tumor biomarker: Regulation of cellular functions via TOB1 in breast cancer.
TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer.
Title: TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer.
LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis.
Title: LncRNA WEE2-AS1 promotes proliferation and inhibits apoptosis in triple negative breast cancer cells via regulating miR-32-5p/TOB1 axis.
The downregulation of DAL-1 and TOB1 expression is associated with shorter survival of gastric cancer patients and may be considered potential novel markers for predicting the outcomes of patients with gastric cancer
Title: Decreased expression levels of DAL-1 and TOB1 are associated with clinicopathological features and poor prognosis in gastric cancer.
TOB1 was found to be directly targeted by miR-371a-3p, in which TOB1 was down-regulated by miR-371a-3p in gastric cancer (GC). Most importantly, results showed that TOB1 plays a tumor-suppressive role in GC cells, and it is required for the miR-371a-3p's oncogenic activities in GC cells.
Title: MicroRNA-371a-3p promotes progression of gastric cancer by targeting TOB1.
Our findings provide important insights into a previously unrecognized oncogenic role of Tob1 in colon cancer and suggest that Tob1 is an adverse prognostic factor and therapeutic target for colon cancer.
Title: High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer.
MiR-590 targets Tob1 that is significantly decreased in patients with multiple sclerosis.
Title: MicroRNA-590 promotes pathogenic Th17 cell differentiation through targeting Tob1 and is associated with multiple sclerosis.
The dual-luciferase reporter assay also confirmed that miR-25 harbored the A allele which caused an incapacitation of binding at the TOB1. In conclusion, rs41274221 in miR-25 was a subgroup which may protect the patients from further growth and metastasis of gastric cancer and might serve as a novel biomarker for the disease
Title: The polymorphism in miR-25 attenuated the oncogenic function in gastric cancer.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1726E (e-PCR)
- UniSTS:153960

PMC196063P2 (e-PCR)
- UniSTS:271794

RH45773 (e-PCR)
- UniSTS:79304

RH71321 (e-PCR)
- UniSTS:92912

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Tob1

Names: proliferation-inducing gene 49; transducer of erbB-2 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243877.2 → NP_001230806.1 protein Tob1 isoform 1

See identical proteins and their annotated locations for NP_001230806.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AK313904, BC031406

Consensus CDS

CCDS11576.1

UniProtKB/Swiss-Prot

B2R9T0, D3DTY3, P50616, Q4KMQ0

UniProtKB/TrEMBL

Q2TU63

Related

ENSP00000268957.3, ENST00000268957.3

Conserved Domains (1) summary

smart00099
Location:1 → 106

btg1; tob/btg1 family
NM_001243885.2 → NP_001230814.1 protein Tob1 isoform 2

See identical proteins and their annotated locations for NP_001230814.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AA675891, AK313904, BC031406, DA039934

UniProtKB/Swiss-Prot

P50616
NM_005749.4 → NP_005740.1 protein Tob1 isoform 1

See identical proteins and their annotated locations for NP_005740.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

BC031406, BC098415, DA039934

Consensus CDS

CCDS11576.1

UniProtKB/Swiss-Prot

B2R9T0, D3DTY3, P50616, Q4KMQ0

UniProtKB/TrEMBL

Q2TU63

Related

ENSP00000427695.1, ENST00000499247.3

Conserved Domains (1) summary

smart00099
Location:1 → 106

btg1; tob/btg1 family