RND3 Rho family GTPase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RND3provided by HGNC
Official Full Name: Rho family GTPase 3provided by HGNC
Primary source: HGNC:HGNC:671
See related: Ensembl:ENSG00000115963 MIM:602924; AllianceGenome:HGNC:671
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARHE; Rho8; RhoE; memB
Summary: This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Expression: Broad expression in esophagus (RPKM 87.1), liver (RPKM 49.1) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q23.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (150468193..150487695, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (150918573..150938077, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (151324707..151344209, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.
Title: KIAA1429 facilitates metastasis via m6A-YTHDC1-dependent RND3 down-regulation in hepatocellular carcinoma cells.
Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma.
Title: Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma.
Rnd3 Is a Crucial Mediator of the Invasive Phenotype of Glioblastoma Cells Downstream of Receptor Tyrosine Kinase Signalling.
Title: Rnd3 Is a Crucial Mediator of the Invasive Phenotype of Glioblastoma Cells Downstream of Receptor Tyrosine Kinase Signalling.
RND3 Transcriptionally Regulated by FOXM1 Inhibits the Migration and Inflammation of Synovial Fibroblasts in Rheumatoid Arthritis Through the Rho/ROCK Pathway.
Title: RND3 Transcriptionally Regulated by FOXM1 Inhibits the Migration and Inflammation of Synovial Fibroblasts in Rheumatoid Arthritis Through the Rho/ROCK Pathway.
Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence.
Title: Silencing of RND3/RHOE inhibits the growth of human hepatocellular carcinoma and is associated with reversible senescence.
HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3.
Title: HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3.
Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers.
Title: Serum levels of cytoskeleton remodeling proteins and their mRNA expression in tumor tissue of metastatic laryngeal and hypopharyngeal cancers.
Effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma.
Title: Effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma.
Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPARgamma-UCP2 cascade.
Title: Maternal RND3/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPARγ-UCP2 cascade.
uncovered a novel differential expression of adipose RND3 in obesity and insulin resistance, which may at least partly depend on a causal effect of RND3 on adipocyte lipolysis.
Title: The Rho GTPase RND3 regulates adipocyte lipolysis.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association search for type 2 diabetes genes in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study link novel loci to endometriosis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif modulates the expression of Rho family GTPase 3 (RND3) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A004G10 (e-PCR)
- UniSTS:2365

RH12568 (e-PCR)
- UniSTS:61817

RH68892 (e-PCR)
- UniSTS:13437

ARHE_2407 (e-PCR)
- UniSTS:280448

A008Z31 (e-PCR)
- UniSTS:21381

RH119779 (e-PCR)
- UniSTS:133255

RH119467 (e-PCR)
- UniSTS:138187

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoE

Names: protein MemB; ras homolog gene family, member E; rho-related GTP-binding protein Rho8; small GTP binding protein Rho8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001254738.1 → NP_001241667.1 rho-related GTP-binding protein RhoE precursor

See identical proteins and their annotated locations for NP_001241667.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC074097, AC093738, AK313224

Consensus CDS

CCDS2190.1

UniProtKB/Swiss-Prot

D3DP95, P52199, P61587

UniProtKB/TrEMBL

B2R838

Related

ENSP00000364886.2, ENST00000375734.6

Conserved Domains (1) summary

cd04172
Location:19 → 200

Rnd3_RhoE_Rho8; Rnd3/RhoE/Rho8 GTPases
NM_005168.5 → NP_005159.1 rho-related GTP-binding protein RhoE precursor

See identical proteins and their annotated locations for NP_005159.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC012513, BX460517, CF127383, DC367501

Consensus CDS

CCDS2190.1

UniProtKB/Swiss-Prot

D3DP95, P52199, P61587

UniProtKB/TrEMBL

B2R838

Related

ENSP00000263895.4, ENST00000263895.9

Conserved Domains (1) summary

cd04172
Location:19 → 200

Rnd3_RhoE_Rho8; Rnd3/RhoE/Rho8 GTPases