Serpini1 serpin family I member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpini1provided by RGD
Official Full Name: serpin family I member 1provided by RGD
Primary source: RGD:619896
See related: Ensembl:ENSRNOG00000010248 AllianceGenome:RGD:619896
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PI-12; raPIT5a
Summary: Enables serine-type endopeptidase inhibitor activity. Involved in positive regulation of neuron projection development and regulation of cell adhesion. Predicted to be located in neuronal cell body and secretory granule lumen. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in familial encephalopathy with neuroserpin inclusion bodies. Orthologous to human SERPINI1 (serpin family I member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 478.8), Adrenal (RPKM 37.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (162645209..162731737)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (160346403..160433135)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (174013058..174111693)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

neuroserpin has a role in oxygen-glucose deprivation- and reoxygenation-treated rat astrocytes
Title: Neuroprotective effect of neuroserpin in oxygen-glucose deprivation- and reoxygenation-treated rat astrocytes in vitro.
The majority of the mutant neuroserpin proteins were found to fold correctly and could still form inhibitory complexes with tissue plasminogen activator (tPA).
Title: An analysis approach to identify specific functional sites in orthologous proteins using sequence and structural information: application to neuroserpin reveals regions that differentially regulate inhibitory activity.
Rats overexpressing neuroserpin also showed a significant decrease in the levels of postsynaptic density protein 95, a major postsynaptic scaffolding protein.
Title: AAV-mediated overexpression of neuroserpin in the hippocampus decreases PSD-95 expression but does not affect hippocampal-dependent learning and memory.
Neuroserpin upregulates in the early period of sustained spinal cord compression.
Title: Neuroserpin upregulates in the early period of sustained spinal cord compression.
Increased expression of neuroserpin is shown to regulate the density of dendritic protrusions and shift morphology to a more immature spine phenotype.
Title: Neuroserpin regulates the density of dendritic protrusions and dendritic spine shape in cultured hippocampal neurons.
Although neuroserpin is expressed during late stage of neurogenesis in development, our results suggest that neuroserpin may play some roles in early stage of neurogenesis in adult rat hippocampus.
Title: Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus.
In nerve cells, neuroserpin may regulate the levels of N-cadherin available for construction, maintenance, and control of synapses and synaptic dynamics.
Title: Neuroserpin regulates N-cadherin-mediated cell adhesion independently of its activity as an inhibitor of tissue plasminogen activator.
neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration
Title: Expression and functional characterization of the serine protease inhibitor neuroserpin in endocrine cells.
neuroserpin interacts with Abeta(1-42) to form off-pathway non-toxic oligomers and so protects neurons in Alzheimer disease
Title: Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.
novel intracellular serpin from the rat pituitary gland; data suggest raPIT5a may regulate apoptosis in the pituitary by inhibition of granzyme B or GLP IIIa, or members of the caspase enzyme family.
Title: Characterisation of two serine protease inhibitors expressed in the pituitary gland.

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General gene information

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Markers

RH140400 (e-PCR)
- UniSTS:222475

RH139560 (e-PCR)
- UniSTS:221645

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle lumen	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle lumen	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in secretory granule lumen	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neuroserpin

Names: peptidase inhibitor 12; protease inhibitor 17; serine (or cysteine) peptidase inhibitor, clade I, member 1; serine (or cysteine) proteinase inhibitor clade member 1; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; serine protease inhibitor 17; serpin I1; serpin peptidase inhibitor, clade I (neuroserpin), member 1; serpin peptidase inhibitor, clade I, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053779.2 → NP_446231.1 neuroserpin precursor

See identical proteins and their annotated locations for NP_446231.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q9JLD1, Q9JLD2

UniProtKB/TrEMBL

A6J5Q7

Related

ENSRNOP00000013905.4, ENSRNOT00000013904.7

Conserved Domains (1) summary

cd02048
Location:23 → 410

neuroserpin; Neuroserpin is a inhibitory member of the SERine Proteinase INhibitor (serpin) family that reacts preferentially with tissue-type plasminogen activator (tPA). It is located in neurons in regions of the brain where tPA is also found, suggesting that ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

162645209..162731737

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281153.1 → XP_063137223.1 neuroserpin isoform X1

UniProtKB/Swiss-Prot

Q9JLD1, Q9JLD2

UniProtKB/TrEMBL

A6J5Q7
XM_008761076.4 → XP_008759298.1 neuroserpin isoform X1

See identical proteins and their annotated locations for XP_008759298.1

UniProtKB/Swiss-Prot

Q9JLD1, Q9JLD2

UniProtKB/TrEMBL

A6J5Q7

Conserved Domains (1) summary

cd02048
Location:23 → 410

neuroserpin; Neuroserpin is a inhibitory member of the SERine Proteinase INhibitor (serpin) family that reacts preferentially with tissue-type plasminogen activator (tPA). It is located in neurons in regions of the brain where tPA is also found, suggesting that ...