Txnl1 thioredoxin-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Txnl1provided by RGD
Official Full Name: thioredoxin-like 1provided by RGD
Primary source: RGD:621717
See related: Ensembl:ENSRNOG00000018818 AllianceGenome:RGD:621717
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Txnl
Summary: Predicted to enable disulfide oxidoreductase activity. Predicted to be located in cytosol. Predicted to be part of proteasome complex. Orthologous to human TXNL1 (thioredoxin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 265.9), Muscle (RPKM 223.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (59397275..59428072, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (57125362..57155167, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (59056454..59086278, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TXNL1 acts as an effector of oxidants or a redox sensor by converting redox changes into changes of GDI capacity to capture Rab5, which in turn modulates fluid phase endocytosis
Title: The redox sensor TXNL1 plays a regulatory role in fluid phase endocytosis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables disulfide oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin-like protein 1

Names: thioredoxin-like (32kD); thioredoxin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080887.2 → NP_543163.1 thioredoxin-like protein 1

See identical proteins and their annotated locations for NP_543163.1

Status: PROVISIONAL

Source sequence(s)

BC098908

UniProtKB/Swiss-Prot

Q920J4

UniProtKB/TrEMBL

A0A8I5ZZI7, A6IXM8

Related

ENSRNOP00000025510.2, ENSRNOT00000025510.5

Conserved Domains (2) summary

cd02947
Location:12 → 104

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

pfam06201
Location:128 → 268

PITH; PITH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

59397275..59428072 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254827.5 → XP_006254889.1 thioredoxin-like protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K737, A0A8I5ZZI7

Related

ENSRNOP00000074049.1

Conserved Domains (2) summary

cd02947
Location:12 → 104

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

pfam06201
Location:126 → 268

PITH; PITH domain
XM_063277080.1 → XP_063133150.1 thioredoxin-like protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZWH0, A0A8I5ZZI7