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    Acp6 acid phosphatase 6, lysophosphatidic [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295305, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Acp6provided by RGD
    Official Full Name
    acid phosphatase 6, lysophosphatidicprovided by RGD
    Primary source
    RGD:1306336
    See related
    Ensembl:ENSRNOG00000017494 AllianceGenome:RGD:1306336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lysophosphatidic acid phosphatase activity. Predicted to be involved in dephosphorylation and lysobisphosphatidic acid metabolic process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to human ACP6 (acid phosphatase 6, lysophosphatidic). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 97.0), Thymus (RPKM 80.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acp6 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (187400786..187421877)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184711975..184733067)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199284177..199305793)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553665 Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1, pseudogene 2 Neighboring gene proline-rich protein 2-like Neighboring gene BCL9, transcription coactivator Neighboring gene uncharacterized LOC102549654

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. Li J, et al. Protein Cell, 2013 Jul. PMID 23807634, Free PMC Article
    2. Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis. Hiroyama M, et al. J Biol Chem, 1999 Oct 8. PMID 10506173
    3. Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum. Takayama I, et al. Gut, 2002 Jun. PMID 12010880, Free PMC Article
    4. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116276

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lysophosphatidic acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophosphatidic acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysobisphosphatidic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysobisphosphatidic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidic acid phosphatase type 6
    NP_001026815.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031645.1 → NP_001026815.1  lysophosphatidic acid phosphatase type 6

      See identical proteins and their annotated locations for NP_001026815.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099131
      UniProtKB/TrEMBL
      F6Q1U6, Q4FZU0
      Related
      ENSRNOP00000044125.3, ENSRNOT00000043194.6
      Conserved Domains (1) summary
      cd07061
      Location:37 → 366
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      187400786..187421877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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