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    Ccnt2 cyclin T2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304758, updated on 5-Mar-2024

    Summary

    Official Symbol
    Ccnt2provided by RGD
    Official Full Name
    cyclin T2provided by RGD
    Primary source
    RGD:1309205
    See related
    Ensembl:ENSRNOG00000017113 AllianceGenome:RGD:1309205
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including 7SK snRNA binding activity; cyclin-dependent protein serine/threonine kinase activator activity; and enzyme binding activity. Predicted to be involved in several processes, including early viral transcription; late viral transcription; and positive regulation of transcription, DNA-templated. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Orthologous to human CCNT2 (cyclin T2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 118.2), Lung (RPKM 114.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ccnt2 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (41804007..41845641)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (39251573..39293172)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (44475959..44516892)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 163 Neighboring gene aminocarboxymuconate semialdehyde decarboxylase Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene RAB3 GTPase activating protein catalytic subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 7SK snRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cyclin/CDK positive transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107171.1NP_001100641.1  cyclin-T2

      See identical proteins and their annotated locations for NP_001100641.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473958
      UniProtKB/TrEMBL
      A6IBW0, D3ZGL6
      Related
      ENSRNOP00000024602.5, ENSRNOT00000024602.8
      Conserved Domains (2) summary
      COG5333
      Location:8216
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
      cd00043
      Location:36108
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      41804007..41845641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249686.5XP_006249748.1  cyclin-T2 isoform X2

      See identical proteins and their annotated locations for XP_006249748.1

      UniProtKB/TrEMBL
      A9CMA7
      Conserved Domains (2) summary
      COG5333
      Location:8216
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
      cd00043
      Location:36108
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    2. XM_063272276.1XP_063128346.1  cyclin-T2 isoform X1

    3. XM_063272277.1XP_063128347.1  cyclin-T2 isoform X3

    4. XM_017598786.2XP_017454275.1  cyclin-T2 isoform X4

      Conserved Domains (1) summary
      cl40454
      Location:18115
      CYCLIN_SF; Cyclin box fold superfamily
    5. XM_063272278.1XP_063128348.1  cyclin-T2 isoform X4

    6. XM_017598787.3XP_017454276.1  cyclin-T2 isoform X5

      Conserved Domains (1) summary
      cl40454
      Location:184
      CYCLIN_SF; Cyclin box fold superfamily
    7. XM_039090688.2XP_038946616.1  cyclin-T2 isoform X6