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    Larp7 La ribonucleoprotein 7, transcriptional regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686883, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Larp7provided by RGD
    Official Full Name
    La ribonucleoprotein 7, transcriptional regulatorprovided by RGD
    Primary source
    RGD:1592474
    See related
    Ensembl:ENSRNOG00000048989 AllianceGenome:RGD:1592474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 7SK snRNA binding activity and U6 snRNA binding activity. Predicted to be involved in several processes, including ncRNA metabolic process; negative regulation of viral transcription; and regulation of RNA metabolic process. Predicted to act upstream of or within several processes, including germ cell proliferation; negative regulation of chromatin binding activity; and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of 7SK snRNP. Orthologous to human LARP7 (La ribonucleoprotein 7, transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 95.1), Liver (RPKM 89.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q42
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (218672145..218687332, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (215997641..216012833, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (231866888..231882002, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ankyrin 2 Neighboring gene adenosylhomocysteinase-like Neighboring gene transfer RNA valine (anticodon AAC) 18 Neighboring gene uncharacterized LOC120101095 Neighboring gene uncharacterized LOC134485763 Neighboring gene zinc finger, GRF-type containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness. Hasler D, et al. Mol Cell, 2020 Mar 5. PMID 32017898
    2. hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA. Eichhorn CD, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27679474, Free PMC Article
    3. Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7. Eichhorn CD, et al. Proc Natl Acad Sci U S A, 2018 Jul 10. PMID 29946027, Free PMC Article
    4. A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP. Xue Y, et al. Nucleic Acids Res, 2010 Jan. PMID 19906723, Free PMC Article
    5. The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression. Egloff S, et al. EMBO J, 2017 Apr 3. PMID 28254838, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 7SK snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 7SK snRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U6 snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables U6 snRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in U6 2'-O-snRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in U6 2'-O-snRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in box C/D sno(s)RNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in box C/D sno(s)RNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within germ cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of snRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of 7SK snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    la-related protein 7
    Names
    La ribonucleoprotein domain family, member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044290.2 → NP_001037755.2  la-related protein 7

      See identical proteins and their annotated locations for NP_001037755.2

      Status: VALIDATED

      Source sequence(s)
      BC083898, FM031800
      UniProtKB/Swiss-Prot
      Q5XI01
      UniProtKB/TrEMBL
      M0R7D1
      Conserved Domains (3) summary
      cd08032
      Location:26 → 106
      LARP_7; La RNA-binding domain of La-related protein 7
      cd12290
      Location:121 → 200
      RRM1_LARP7; RNA recognition motif 1 in La-related protein 7 (LARP7) and similar proteins
      pfam08777
      Location:443 → 541
      RRM_3; RNA binding motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      218672145..218687332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103144.2 → XP_038959072.1  la-related protein 7 isoform X3

      UniProtKB/TrEMBL
      M0R7D1
      Related
      ENSRNOP00000065357.3
      Conserved Domains (3) summary
      cd08032
      Location:26 → 106
      LARP_7; La RNA-binding domain of La-related protein 7
      cd12290
      Location:121 → 200
      RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
      cd12542
      Location:444 → 525
      RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

    2. XM_039103143.2 → XP_038959071.1  la-related protein 7 isoform X2

      UniProtKB/TrEMBL
      M0R7D1
      Conserved Domains (3) summary
      cd08032
      Location:32 → 112
      LARP_7; La RNA-binding domain of La-related protein 7
      cd12290
      Location:127 → 206
      RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
      cd12542
      Location:449 → 530
      RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins

    3. XM_039103142.2 → XP_038959070.1  la-related protein 7 isoform X1

      UniProtKB/TrEMBL
      M0R7D1, M0RC12
      Related
      ENSRNOP00000067115.3
      Conserved Domains (3) summary
      cd08032
      Location:32 → 112
      LARP_7; La RNA-binding domain of La-related protein 7
      cd12290
      Location:127 → 206
      RRM1_LARP7; RNA recognition motif 1 (RRM1) found in La-related protein 7 (LARP7) and similar proteins
      cd12542
      Location:450 → 531
      RRM2_LARP7; RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI01.2 GenPept UniProtKB/Swiss-Prot:Q5XI01

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