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    Marchf1 membrane associated ring-CH-type finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361135, updated on 13-Apr-2024

    Summary

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    Symbol
    Marchf1provided by RGD
    Full Name
    membrane associated ring-CH-type finger 1provided by RGD
    Primary source
    RGD:1305148
    See related
    Ensembl:ENSRNOG00000026310 AllianceGenome:RGD:1305148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    March1; RGD1305148
    Summary
    Predicted to enable MHC protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in antigen processing and presentation of peptide antigen via MHC class II; immune response; and protein polyubiquitination. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; lysosomal membrane; and trans-Golgi network membrane. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Orthologous to human MARCHF1 (membrane associated ring-CH-type finger 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 150.6), Thymus (RPKM 36.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16p14-p13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (28022159..28880872, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (23255551..24114290, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (24998709..25856327, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene transketolase-like 2 Neighboring gene translation machinery associated 16 homolog Neighboring gene 60S ribosomal protein L22-like 1 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120097418 Neighboring gene BCL2 interacting protein 3, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, pseudogene 2 Neighboring gene uncharacterized LOC134482491 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression. Jabbour M, et al. J Immunol, 2009 Nov 15. PMID 19880452, Free PMC Article
    2. Novel regulation of MHC class II function in B cells. Matsuki Y, et al. EMBO J, 2007 Feb 7. PMID 17255932, Free PMC Article
    3. Interleukin-10-induced MARCH1 mediates intracellular sequestration of MHC class II in monocytes. Thibodeau J, et al. Eur J Immunol, 2008 May. PMID 18389477, Free PMC Article
    4. Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells. Ohmura-Hoshino M, et al. J Immunol, 2009 Dec 1. PMID 19917682
    5. MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nagarajan A, et al. Nat Commun, 2016 Aug 31. PMID 27577745, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MHC protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF1
    Names
    E3 ubiquitin-protein ligase MARCH1
    E3 ubiquitin-protein ligase MARCH1-like
    membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
    NP_001129310.1
    NP_001388434.1
    XP_008769356.3
    XP_017455664.2
    XP_017455665.2
    XP_038950560.1
    XP_038950561.1
    XP_038950562.1
    XP_038950563.1
    XP_063131582.1
    XP_063131583.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135838.2 → NP_001129310.1  E3 ubiquitin-protein ligase MARCHF1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      D4A6K8
      Related
      ENSRNOP00000038896.4, ENSRNOT00000032289.4
      Conserved Domains (1) summary
      cd16698
      Location:75 → 126
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    2. NM_001401505.1 → NP_001388434.1  E3 ubiquitin-protein ligase MARCHF1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      28022159..28880872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600176.3 → XP_017455665.2  E3 ubiquitin-protein ligase MARCHF1 isoform X2

      Conserved Domains (1) summary
      cd16698
      Location:332 → 383
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    2. XM_039094632.2 → XP_038950560.1  E3 ubiquitin-protein ligase MARCHF1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH31
      Related
      ENSRNOP00000092175.1
      Conserved Domains (1) summary
      cd16698
      Location:332 → 383
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    3. XM_039094634.2 → XP_038950562.1  E3 ubiquitin-protein ligase MARCHF1 isoform X3

      Conserved Domains (1) summary
      cd16698
      Location:328 → 379
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    4. XM_008771134.4 → XP_008769356.3  E3 ubiquitin-protein ligase MARCHF1 isoform X5

      Conserved Domains (1) summary
      cd16698
      Location:79 → 130
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    5. XM_039094635.2 → XP_038950563.1  E3 ubiquitin-protein ligase MARCHF1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AQF1
      Related
      ENSRNOP00000096247.1
      Conserved Domains (1) summary
      cd16698
      Location:79 → 130
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    6. XM_063275512.1 → XP_063131582.1  E3 ubiquitin-protein ligase MARCHF1 isoform X3

    7. XM_039094633.2 → XP_038950561.1  E3 ubiquitin-protein ligase MARCHF1 isoform X3

      Conserved Domains (1) summary
      cd16698
      Location:328 → 379
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    8. XM_017600175.3 → XP_017455664.2  E3 ubiquitin-protein ligase MARCHF1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AH31
      Conserved Domains (1) summary
      cd16698
      Location:332 → 383
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    9. XM_063275513.1 → XP_063131583.1  E3 ubiquitin-protein ligase MARCHF1 isoform X6

      UniProtKB/TrEMBL
      A6KFM4
    Nucleotide Protein Strain
    Heading Accession and Version

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