Cpt2 carnitine palmitoyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpt2provided by RGD
Official Full Name: carnitine palmitoyltransferase 2provided by RGD
Primary source: RGD:2398
See related: Ensembl:ENSRNOG00000012443 AllianceGenome:RGD:2398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CPTII
Summary: Enables carnitine O-palmitoyltransferase activity. Involved in fatty acid beta-oxidation and response to fatty acid. Located in mitochondrion. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 712.7), Adrenal (RPKM 449.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (127893450..127911347, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (122664677..122682126, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (127505646..127523016, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.
Title: GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.
Unique Behavior of Bacterially Expressed Rat Carnitine Palmitoyltransferase 2 and Its Catalytic Activity.
Title: Unique Behavior of Bacterially Expressed Rat Carnitine Palmitoyltransferase 2 and Its Catalytic Activity.
The effects of exercise on skeletal and heart muscle citrate synthase and carnitine palmitoyltransferase mRNA expressions in high-calorie fed rats.
Title: The effects of exercise on skeletal and heart muscle citrate synthase and carnitine palmitoyltransferase mRNA expressions in high-calorie fed rats.
Low CPT-II expression might lead to abnormal hepatic lipid accumulation, which should promote the malignant transformation of hepatocytes.
Title: Mitochondrial carnitine palmitoyl transferase-II inactivity aggravates lipid accumulation in rat hepatocarcinogenesis.
Report interaction between carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase supporting the channeling of acylcarnitines and carnitine at level of the inner mitochondrial membrane.
Title: Carnitine/acylcarnitine translocase and carnitine palmitoyltransferase 2 form a complex in the inner mitochondrial membrane.
The protein interacts with the membrane as a functional monomer and the calculations confirm the presence of a membrane association domain that consists of layers of hydrophobic and positively charged residues.
Title: Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog.
crystal structure of carnitine palmitoyltransferase 2
Title: The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment.
role of highly conserved C-terminal acidic residues glutamate 487 and glutamate 500 on catalytic activity in liver
Title: Identification by mutagenesis of a conserved glutamate (Glu487) residue important for catalytic activity in rat liver carnitine palmitoyltransferase II.
surface patch mediates the association of CPT-II with the inner membrane of the mitochondria
Title: Crystal structure of rat carnitine palmitoyltransferase II (CPT-II).

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cpt2 (e-PCR), detects polymorphism
- UniSTS:518545

AI323697 (e-PCR)
- UniSTS:165340

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables carnitine O-octanoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carnitine O-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carnitine O-palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables carnitine O-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carnitine O-palmitoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carnitine O-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carnitine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carnitine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in carnitine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	IEP Inferred from Expression Pattern more info	PubMed
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid beta-oxidation	TAS Traceable Author Statement more info	PubMed
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in long-chain fatty acid transport	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carnitine O-palmitoyltransferase 2, mitochondrial

Names: carnitine palmitoyltransferase II

XP_038965227.1

EC 2.3.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429334.1 → NP_001416263.1 carnitine O-palmitoyltransferase 2, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P18886, P97781
NM_001429335.1 → NP_001416264.1 carnitine O-palmitoyltransferase 2, mitochondrial isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P18886, P97781
NM_001429336.1 → NP_001416265.1 carnitine O-palmitoyltransferase 2, mitochondrial isoform 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZW87
NM_012930.2 → NP_037062.2 carnitine O-palmitoyltransferase 2, mitochondrial isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P18886, P97781

UniProtKB/TrEMBL

A6JYT6, G3V7N5

Related

ENSRNOP00000016954.1, ENSRNOT00000016954.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

127893450..127911347 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109299.2 → XP_038965227.1 carnitine O-palmitoyltransferase 2, mitochondrial isoform X1

Conserved Domains (1) summary

pfam00755
Location:49 → 584

Carn_acyltransf; Choline/Carnitine o-acyltransferase