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    Nat1 N-acetyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116631, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nat1provided by RGD
    Official Full Name
    N-acetyltransferase 1provided by RGD
    Primary source
    RGD:70490
    See related
    Ensembl:ENSRNOG00000049498 AllianceGenome:RGD:70490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nat
    Summary
    Enables arylamine N-acetyltransferase activity. Involved in aging; liver development; and response to thyroxine. Located in cytosol. Human ortholog(s) of this gene implicated in carcinoma (multiple); contact dermatitis (multiple); pancreatic cancer; and prostate cancer. Orthologous to human NAT1 (N-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
    Expression
    Biased expression in Liver (RPKM 127.8), Spleen (RPKM 82.7) and 9 other tissues See more
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    Genomic context

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    Location:
    16p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (26984882..27005194, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (22218217..22238516, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (23970742..23991573, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene pleckstrin and Sec7 domain containing 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene N-acetyltransferase 3 Neighboring gene high mobility group box 2, pseudogene 3 Neighboring gene N-acetyltransferase 2 Neighboring gene golgin A4, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel translational repressor (NAT-1) expression is modified by thyroid state and age in brain and liver. Shah GN, et al. Eur J Endocrinol, 1998 Dec. PMID 9916872
    2. Association of the NAT1*10 genotype with increased chromosome aberrations and higher lung cancer risk in cigarette smokers. Abdel-Rahman SZ, et al. Mutat Res, 1998 Feb 26. PMID 9626964
    3. Combination therapy with 5-azacytidine plus beta-2'-deoxythioguanosine in adult acute leukemia. Omura GA. Cancer Treat Rep, 1977 Aug. PMID 70273
    4. Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells. Liu YJ, et al. J Pineal Res, 2012 May. PMID 22225631
    5. 4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat. Zhang X, et al. J Pharmacol Exp Ther, 2006 Jan. PMID 16192314

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A higher level of melatonin was demonstrated in cultured ApoE4-C6 cells than in ApoE3-C6 cells. NAT was up-regulated in ApoE4-C6 cells compared with ApoE3-C6 cells, and MAOA and MAOB expression decreased in ApoE4-C6 cells.
      Title: Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells.
    2. The expressions of Clock and NAT genes in the pineal gland not only show remarkably synchronous endogenous circadian rhythmic changes, but also response to the ambient light signal in a reduced manner.
      Title: [Circadian rhythms and light responses of clock gene and arylalkylamine N-acetyltransferase gene expressions in the pineal gland of rats].
    3. Results demonstrate differential tissue-specific and developmental regulation of the rat Nat1 and Nat2 genes.
      Title: Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat.
    4. RT-PCR experiments demonstrated that the relative expression of the rNat transcripts in liver and 12 extrahepatic tissues was rNat1 > rNat2, while rNat3 transcripts were not detected.
      Title: Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arylamine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arylamine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arylamine N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to thyroxine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arylamine N-acetyltransferase 1
    Names
    AT-1
    N-acetyltransferase (arylamine N-acetyltransferase)
    N-acetyltransferase 1 (arylamine N-acetyltransferase)
    N-acetyltransferase type 1
    NAT-1
    arylamide acetylase 1
    NP_001032392.1
    NP_001032393.1
    NP_446305.1
    XP_006253063.1
    XP_006253064.1
    XP_006253066.1
    XP_017455466.1
    XP_017455467.1
    XP_038950079.1
    XP_038950080.1
    XP_038950081.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037315.1 → NP_001032392.1  arylamine N-acetyltransferase 1

      See identical proteins and their annotated locations for NP_001032392.1

      Status: VALIDATED

      Source sequence(s)
      BC078765, U01343
      UniProtKB/Swiss-Prot
      P50297
      UniProtKB/TrEMBL
      Q45G61, Q45G71
      Related
      ENSRNOP00000018854.3, ENSRNOT00000018854.7
      Conserved Domains (1) summary
      pfam00797
      Location:20 → 280
      Acetyltransf_2; N-acetyltransferase

    2. NM_001037316.2 → NP_001032393.1  arylamine N-acetyltransferase 1

      See identical proteins and their annotated locations for NP_001032393.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      P50297
      UniProtKB/TrEMBL
      Q45G61, Q45G71
      Conserved Domains (1) summary
      pfam00797
      Location:20 → 280
      Acetyltransf_2; N-acetyltransferase

    3. NM_053853.2 → NP_446305.1  arylamine N-acetyltransferase 1

      See identical proteins and their annotated locations for NP_446305.1

      Status: VALIDATED

      Source sequence(s)
      BC078765, CB580886
      UniProtKB/Swiss-Prot
      P50297
      UniProtKB/TrEMBL
      Q45G61, Q45G71
      Conserved Domains (1) summary
      pfam00797
      Location:20 → 280
      Acetyltransf_2; N-acetyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      26984882..27005194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253001.4 → XP_006253063.1  arylamine N-acetyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_006253063.1

      UniProtKB/Swiss-Prot
      P50297
      UniProtKB/TrEMBL
      Q45G61, Q45G71
      Related
      ENSRNOP00000070053.1
      Conserved Domains (1) summary
      pfam00797
      Location:20 → 280
      Acetyltransf_2; N-acetyltransferase

    2. XM_006253002.5 → XP_006253064.1  arylamine N-acetyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_006253064.1

      UniProtKB/Swiss-Prot
      P50297
      UniProtKB/TrEMBL
      Q45G61, Q45G71
      Conserved Domains (1) summary
      pfam00797
      Location:20 → 280
      Acetyltransf_2; N-acetyltransferase

    3. XM_039094153.2 → XP_038950081.1  arylamine N-acetyltransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      P50297
      UniProtKB/TrEMBL
      Q45G61, Q45G71
      Conserved Domains (1) summary
      pfam00797
      Location:20 → 280
      Acetyltransf_2; N-acetyltransferase

    4. XM_039094151.2 → XP_038950079.1  arylamine N-acetyltransferase 1 isoform X3

      Conserved Domains (1) summary
      pfam00797
      Location:23 → 283
      Acetyltransf_2; N-acetyltransferase

    5. XM_017599977.3 → XP_017455466.1  arylamine N-acetyltransferase 1 isoform X1

    6. XM_039094152.2 → XP_038950080.1  arylamine N-acetyltransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      P50297
      UniProtKB/TrEMBL
      Q45G61, Q45G71
      Conserved Domains (1) summary
      pfam00797
      Location:20 → 280
      Acetyltransf_2; N-acetyltransferase

    7. XM_006253004.5 → XP_006253066.1  arylamine N-acetyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_006253066.1

      UniProtKB/Swiss-Prot
      P50297
      UniProtKB/TrEMBL
      Q45G61, Q45G71
      Conserved Domains (1) summary
      pfam00797
      Location:20 → 280
      Acetyltransf_2; N-acetyltransferase

    8. XM_017599978.3 → XP_017455467.1  arylamine N-acetyltransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      P50297
      UniProtKB/TrEMBL
      Q45G61, Q45G71
      Related
      ENSRNOP00000086645.1
      Conserved Domains (1) summary
      pfam00797
      Location:20 → 280
      Acetyltransf_2; N-acetyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50297.1 GenPept UniProtKB/Swiss-Prot:P50297

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