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    Abca9 ATP-binding cassette, sub-family A member 9 [ Mus musculus (house mouse) ]

    Gene ID: 217262, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Abca9provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family A member 9provided by MGI
    Primary source
    MGI:MGI:2386796
    See related
    Ensembl:ENSMUSG00000041797 AllianceGenome:MGI:2386796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D630040K07Rik
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Located in mitochondrion. Is expressed in brain meninges; embryo mesenchyme; musculature; and tail. Orthologous to human ABCA9 (ATP binding cassette subfamily A member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 4.2), bladder adult (RPKM 3.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E1; 11 73.22 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109990919..110059532, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (110100749..110168274, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A member 8b Neighboring gene STARR-seq mESC enhancer starr_31033 Neighboring gene ATP-binding cassette, sub-family A member 8a Neighboring gene ATP-binding cassette, sub-family A member 6 Neighboring gene STARR-seq mESC enhancer starr_31035 Neighboring gene STARR-positive B cell enhancer ABC_E10728 Neighboring gene STARR-positive B cell enhancer mm9_chr11:110133108-110133408 Neighboring gene STARR-seq mESC enhancer starr_31036 Neighboring gene ATP-binding cassette, sub-family A member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver. Wakaumi M, et al. Clin Exp Pharmacol Physiol, 2005 Dec. PMID 16445568
    2. Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes. Annilo T, et al. Mamm Genome, 2003 Jan. PMID 12532264
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family A member 9
    Names
    ATP-binding cassette transporter sub-family A member 9
    ATP-binding cassette, sub-family A (ABC1), member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_147220.2 → NP_671753.2  ATP-binding cassette sub-family A member 9

      See identical proteins and their annotated locations for NP_671753.2

      Status: VALIDATED

      Source sequence(s)
      AL603792
      Consensus CDS
      CCDS25589.1
      UniProtKB/Swiss-Prot
      A2A6R5, Q8C114, Q8K449
      Related
      ENSMUSP00000036338.4, ENSMUST00000044850.4
      Conserved Domains (1) summary
      TIGR01257
      Location:128 → 1600
      rim_protein; retinal-specific rim ABC transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      109990919..110059532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156602.1 → XP_036012495.1  ATP-binding cassette sub-family A member 9 isoform X1

      UniProtKB/Swiss-Prot
      A2A6R5, Q8C114, Q8K449
      Conserved Domains (1) summary
      TIGR01257
      Location:128 → 1600
      rim_protein; retinal-specific rim ABC transporter

    2. XM_017314486.3 → XP_017169975.1  ATP-binding cassette sub-family A member 9 isoform X1

      UniProtKB/Swiss-Prot
      A2A6R5, Q8C114, Q8K449
      Conserved Domains (1) summary
      TIGR01257
      Location:128 → 1600
      rim_protein; retinal-specific rim ABC transporter

    3. XM_036156603.1 → XP_036012496.1  ATP-binding cassette sub-family A member 9 isoform X2

      Conserved Domains (1) summary
      TIGR01257
      Location:11 → 1280
      rim_protein; retinal-specific rim ABC transporter

    4. XM_017314487.3 → XP_017169976.1  ATP-binding cassette sub-family A member 9 isoform X2

      Conserved Domains (1) summary
      TIGR01257
      Location:11 → 1280
      rim_protein; retinal-specific rim ABC transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K449.2 GenPept UniProtKB/Swiss-Prot:Q8K449

    Gene LinkOut

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